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MetabolomicsRegulation mechanism of gibberellic acid-3 for astaxanthin biosynthesis in heterotrophically growing Chromochloris zofingiensis

Chromochloris zofingiensis has been proved as a potential resource for large-scale astaxanthin production, but little information of phytohormones on growth and astaxanthin accumulation could be obtained. This study explored the impact of gibberellic acid-3 (GA3) on growth and astaxanthin generat...

2024-08-13 | MTBLS10762 | MetaboLights
MetabolomicsAstaxanthin improve the intestinal flora and metabolism after ischemic stroke

Abstract: 

Background and Objective. As a prevalent cerebrovascular disorder, the association between ischemic stroke and gut microbiota has garnered increasing attention. Recent studies have confirmed that astaxanthin exhibits significant protective effects against ischemic stroke. Ho...

2025-10-15 | MTBLS13080 | MetaboLights
MetabolomicsAstaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella muris

Oxidative stress and ferroptosis are central to the pathogenesis of many diseases, including those characterized by intestinal damage, where excessive lipid peroxidation and iron accumulation trigger cellular dysfunction. In this study, we investigate the protective effects of astaxanthin (ASTA),...

2025-10-14 | MTBLS13140 | MetaboLights
TranscriptomicsTranscriptome analysis in Haematococcus pluvialis: astaxanthin induction by salicylic acid (SA) and jasmonic acid (JA)
Haematococcus pluvialis transcriptome analysis The genetic transcriptome details of astaxanthin biosynthesis were analysed by exposing the algal cells to 25 mg/L of SA and JA for 1, 6 and 24 hours, plus to the control (no stress). SRP062153 PRJNA292140
ORGANISM(S): Haematococcus pluvialis 
2016-02-15 | E-GEOD-71986 | biostudies-arrayexpress
ProteomicsAstaxanthin Supplementation Counters Exercise-Induced Decreases in Immune- Related Plasma Proteins
Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory, and anti-inflammatory effects during physiological stress. The primary...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040503 | Pride
Astaxanthin High-throughput plasma proteomics Shtpp 
ProteomicsTandem Mass Tag-based proteomics of astaxanthin-producing tobacco expressing astaxanthin synthetases from Adonis aestivalis
The synthesis of astaxanthin leads to growth retardation in tobacco. Meanwhile, irregular mosaic pigmentation randomly appears on the leaves of astaxanthin-producing tobacco. The purpose of this project is to elucidate the mechanism of growth retardation in astaxanthin-producing tobacco and to compa...
ORGANISM(S): Nicotiana Tabacum 
2024-03-05 | PXD050349 |
GenomicsDifferential transcriptomic expression of an imprved astaxanthin production
Differential transcriptomic expression of an imprved astaxanthin production
PRJNA880907 | ENA
ProteomicsPlasma-based proteomics analysis of molecular pathways in canine diabetes mellitus after astaxanthin supplementation
The hyperglycemic state in diabetes mellitus (DM) induces oxidative stress and inflammation, thus contributing to diabetic tissue damage and associated complications. Astaxanthin, a potent antioxidant carotenoid, has been investigated for its potential in preventing and managing diabetes across vari...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-03-17 | PXD055138 | Pride
Astaxanthin Plasma proteomic Inflammation Canine diabetic mellitus Oxidative stress 
TranscriptomicsDifferential transcriptomic expression of an imprved astaxanthin production
The differential expression of the high-yield astaxanthin Phaffia rhodozyma BPAX-A1 with the wild-type Phaffia rhodozyma CBS6938 was obtained and analysed to understand metabolic changes leading to an improved astaxanthin production.
ORGANISM(S): Phaffia rhodozyma 
2023-09-14 | GSE213476 | GEO
ProteomicsExploring the high light stress response of a Haematococcus pluvialis (Chlorophyceae) mutant with a higher astaxanthin content via proteomic and phosphoproteomic analysis reveals altered chlorophyll biosynthesis, carbon partitioning, and astaxanthin biosynthesis and trafficking
While the green microalga, Haematococcus pluvialis, is the best natural producer of astaxanthin, efforts to grow it for astaxanthin production are still limited by its low biomass productivity which subsequently results in lower astaxanthin productivity. Despite new methods of direct strain modifica...
ORGANISM(S): Haematococcus lacustris 
2026-01-24 | PXD060374 | Pride
Lipid Proteomics Post-translational modification High light stress Astaxanthin Phosphoproteomics Chlorophyll biosynthesis Cell cycle control 
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