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MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
TranscriptomicsTranscription profiling by array of human astrocytes derived from trisomic human embryonic stem cells
Astrocytes derived from normal and aneuploid human embryonic stem cells, along with CCF-STTG1 astrocytoma cell line, and using three biological replicates for each sample, were used to develop an in-vitro model system, to identify biomarkers for astrocytic cancer cells and premalignant stem-like pro...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-MEXP-2633 | biostudies-arrayexpress
TranscriptomicsSox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
Making use of a previously described isogenic cancer stem cells and serum differentiated cultures we show that Sox2 controls developmental stated specific programs in glioblastoma. Glioblastoma cells were cultured as control and with SOX2 knockdown to identify the scope of SOX2 interactions. The SOX...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-51441 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human grade II astrocytic tumor (astrocytomas) vs grade IV tumors (glioblastoma)
Comparison of grade II astrocytic tumor (astrocytomas) with grade IV tumors (glioblastoma)
ORGANISM(S): Homo sapiens 
2007-03-01 | E-MEXP-567 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Profiling of Astrocytic Gliomas
Genomic aberrations were determined by array-based comparative genomic hybridization in 131 diffuse astrocytic gliomas, including 87 primary glioblastomas (pGBIV), 13 secondary glioblastomas (sGBIV), 19 anaplastic astrocytomas (AAIII), and 12 diffuse astrocytomas (AII). Expression profiling was perf...
ORGANISM(S): Homo sapiens 
2010-09-14 | E-GEOD-18166 | biostudies-arrayexpress
TranscriptomicsExpression profiling of lower-grade diffuse astrocytic glioma
Diffuse gliomas represent the most prevalent class of primary brain tumor. Despite significant recent advances in the understanding of glioblastoma (WHO IV), its most malignant subtype, lower-grade (WHO II and III) glioma variants remain comparatively understudied, especially in light of their nota...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-35158 | biostudies-arrayexpress
Proteomicskaempferitrin-induced secretome analyses in rat CTX TNA2 astrocytic cell line
Kaempferitrin is extracted at significant quantity from leaves of Cinnamomum osmophloeum. People consuming extract containing kaempferitrin often happen to be of high risk for diabetes and neurodegenerative diseases. For kaempferitrin to be used every day for them, the systematic effect, especially ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-24 | PXD002814 | Pride
Kaempferitrin Secretome Lc-ms/ms Astrocyte 
GenomicsDynamic astrocytic gene expression profiles after ischemic stroke
Dynamic astrocytic gene expression profiles after ischemic stroke
PRJNA997998 | ENA
TranscriptomicsReal-time quantitative PCR analysis of human astrocytomas
Pediatric astrocytomas, a leading cause of death associated with cancer, are the most common primary central nervous system tumors found in children. Most studies of these tumors focus on adults, not children. We examined the global protein and microRNAs expression pattern by 2D SDS-PAGE, mass spect...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44280 | biostudies-arrayexpress
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