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MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
TranscriptomicsGene expression data from the ATAD3A stable knockdown MDA-MB-231 cells and the control cells
From our previous data, we found that loss of ATAD3A gene expression in breast cancer cells results in loss of cell motility in vitro and metastasis in vivo. To obtain a better understanding of oncogenic pathway of ATAD3A, we have established the stable ATAD3A knockdown MDA-MB-231 cells using lentiv...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-56084 | biostudies-arrayexpress
ProteomicsATAD3A heterzygous AD mouse brain, LC-MS
Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATAD3A, a mitochondrial AAA-ATPase, as a molecular switch that links cholesterol metabolism impairment to AD phenotypes. In neuronal models of...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-11 | PXD031523 | Pride
Lc-ms Atad3a heterzygous Mouse brain 
ProteomicsAstrocytic glycogen induces ATAD3A oligomerization-dependent mitochondrial fragmentation to exacerbate neuropathology and delay recovery after ischemic stroke
Ischemic stroke induces pathological glycogen deposition in astrocytes, but its role in post-injury neural dysfunction remains undefined. We firstly intend to identify the glycogen granule proteome after ischemic stroke via glycogen pulldown for protein mass spectrometry detection. KEGG pathway anal...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-11 | PXD064814 | Pride
Atad3a glycogen astrocyte 
ProteomicsAstrocytic glycogen induces ATAD3A oligomerization-dependent mitochondrial fragmentation to exacerbate neuropathology and delay recovery after ischemic stroke
Ischemic stroke induces pathological glycogen deposition in astrocytes, but its role in post-injury neural dysfunction remains undefined. We firstly intend to identify the glycogen granule proteome after ischemic stroke via glycogen pulldown for protein mass spectrometry detection. KEGG pathway anal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064694 | Pride
Stroke Glycogen Atad3a 
ProteomicsAstrocytic glycogen induces ATAD3A oligomerization-dependent mitochondrial fragmentation to exacerbate neuropathology and delay recovery after ischemic stroke
Ischemic stroke induces pathological glycogen deposition in astrocytes, but its role in post-injury neural dysfunction remains undefined. We firstly intend to identify the glycogen granule proteome after ischemic stroke via glycogen pulldown for protein mass spectrometry detection. KEGG pathway anal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD064400 | Pride
Stroke Glycogen Atad3a 
GenomicsATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation
ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation
PRJNA1458662 | ENA
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of HN12 Cell Transcriptome with ATAD3A loss
Next Generation Sequencing Facilitates Quantitative Analysis of HN12 Cell Transcriptome with ATAD3A loss
PRJNA688289 | ENA
TranscriptomicsATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation
Background: Aortic aneurysm and dissection (AAD) is a fatal vascular emergency with limited mechanism-based therapies. The mitochondrial AAA⁺ ATPase ATAD3A, enriched at organelle contact sites, has been implicated in mitochondrial signaling, but its role in AAD remains unclear. Methods: AAD was indu...
ORGANISM(S): Mus musculus 
2026-06-20 | GSE329337 | GEO
GenomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
PRJNA773755 | ENA
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