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MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
ProteomicsProteome of human and mouse astrocytes and astrocyte-conditioned medium
Proteome of human and mouse astrocytes and astrocyte-conditioned medium
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-02-05 | PXD060495 |
ProteomicsProteomics of TurboID-induced biotinylated proteins from astrocyte and astrocyte endeet after acute peripheral inflammation
The brain vasculature is tightly regulated to control the exchange of substances between the periphery and the brain parenchyma at an interface called the blood-brain barrier (BBB). Astrocytes are glial cells that wrap the brain vasculature with a specialised structure called the endfoot, which is a...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD056232 | Pride
Mouse Brain Dia Ip Endfoot Isolation Astrocyte 
ProteomicsDevelopmental alcohol exposure leads to a persistent change on astrocyte secretome
Glial cells are central players in the pathogenesis of neurodevelopmental disorders like Fetal Alcohol Spectrum Disorder (FASD). Ethanol can modulate glial differentiation and astrocyte function imposing dramatic changes to the developing brain. Since ethanol can affect a vast number of intracellula...
ORGANISM(S): Mustela putorius furo (European domestic ferret) (Mustela furo) 
2016-02-15 | PXD002787 | Pride
Astrocytes Secretome Ethanol Fasd 
ProteomicsMouse brain perivascular astrocyte endfoot proteome
Proteome analysis of isolated mouse brain blood vessels and perivascular astrocyte endfeet (PV-AEF) using DIA.
ORGANISM(S): Mus Musculus (mouse) 
2023-11-04 | PXD037949 | JPOST Repository
ModelsMartínJiménez2017 - Genome-scale reconstruction of the human astrocyte metabolic network
MartínJiménez2017 - Genome-scale reconstruction of the human astrocyte metabolic network This model is described in the article: Genome-Scale Reconstruction of the Human Astrocyte Metabolic Network. Martín-Jiménez CA, Salazar-Barreto D, Barreto GE, González J. Front Aging Neur...
2017-05-18 | MODEL1608180000 | BioModels
TranscriptomicsInflammatory mediators alter astrocyte genomic profiles and G-protein receptor evoked calcium signaling
Inflammation features in diverse central nervous system disorders such as stroke, trauma, neurodegeneration, infection and autoimmunity. To better understand how inflammatory mediators may alter astrocyte functions, we examined the effects of transforming growth factor-β1 (TGF-β1), lipopolysacchar...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-36089 | biostudies-arrayexpress
MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
TranscriptomicsTranscription profiling of rat astrocyte cell line RCG-12 to investigate cell growth arrest and differentiation
We performed global scale microarray analysis to identify detailed mechanisms by which nonpermissive temperature induces cell growth arrest and differentiation in astrocyte RCG-12 cells harboring temperature-sensitive simian virus 40 large T-antigen by using an Affymetrix GeneChip system. Astrocyte ...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7501 | biostudies-arrayexpress
TranscriptomicsAstrocyte-encoded positional cues maintain sensorimotor circuit integrity
Astrocytes, the most abundant cells in the central nervous system, promote synapse formation and help refine neural connectivity. Although they are allocated to spatially distinct regional domains during development, it is unknown whether region-restricted astrocytes are functionally heterogeneous. ...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-55054 | biostudies-arrayexpress
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