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MetabolomicsRS5-lycopene complex alleviates diabetic glycogen fragility

This study demonstrates for the first time that CS-LYC, an RS5-based starch-lycopene complex, alleviates T2DM via gut microbiota-mediated regulation, providing novel evidence supporting starch-based functional foods in T2DM management.

2026-02-05 | MTBLS13849 | MetaboLights
MetabolomicsCorpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))

Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal c...

2026-06-12 | MTBLS14754 | MetaboLights
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscles from mice with genetically modified muscle glycogen content to study the impact of glycogen content on gene expression.
Anterior tibialis removed from 3-month old muscle glycogen synthase WT or knockout mouse. RNA was extracted using GibcoBRL TRIzol Reagent and a Quiagen RNeasy kit. Targets were produced using standard Affymetrix procedures from about 5ug of total RNA. GSM40057-GSM40063 AND GSM40956. Liver removed fr...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2198 | biostudies-arrayexpress
ProteomicsGlycogen synthesis jump-starts photosynthesis through the G6P shunt in cyanobacteria
Proteomics analysis on Synechococcus elongatus PCC 7942 wild type and glycogen mutant cells. Cells growing under the light and dark incubated cells were analyzed for their protein abundance profile.
ORGANISM(S): Synechococcus Elongatus Pcc 7942 (ncbitaxon:1140) 
2019-03-14 | MSV000083575 | MassIVE
ProteomicsLIver Glycogen SWATH Proteomics
Identification and relative quantification of proteins associated with mammalian liver glycogen.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-07-23 | PXD009140 | Pride
Glycogen Human Liver Mouse Glycogenin Rat 
ProteomicsExercise-induced molecular mechanisms for glycogen supercompensation in human skeletal muscle
A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in the prior exercised muscle. The molecular mechanisms underlying this well-known phenomenon remain elusive. Here we report that a single bout of exercise induces marked activation of glycogen synthase...
ORGANISM(S): Homo sapiens (Human) 
2018-08-30 | PXD009196 | Pride
Human skeletal muscle exercise glycogen 
MetabolomicsLimitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics
Practical diets for commercial barramundi production rarely contain greater than 10% starch, used mainly as a binding agent during extrusion. Alternative ingredients such as digestible starch have shown some capacity to spare dietary protein catabolism to generate glucose. In the present study, a ca...
2020-07-30 | MTBLS1103 | MetaboLights
MetabolomicsStable isotope resolved analysis of HUVEC Cells under normaxia and hypoxia
In order to analyze HUVECs under normoxia and hypoxia, cells were initially deprived of excess nutrients and hormones by maintaining them overnight in a restricted medium with only 2% fetal bovine serum, and incubated for 40 hours in the presence of the tracer [1,2-13C2]-glucose until sample collect...
2017-12-18 | MTBLS412 | MetaboLights
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