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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
ProteomicsIsolation and mass spectrometry analysis of Atg9 vesicles from Saccharomyces cerevisiae
Autophagy is a eukaryotic bulk degradation pathway that allows cells to degrade potentially harmful cytosolic components or to provide necessary nutrients during starvation. This cargo degradation is achieved by its sequestration within double membrane vesicles termed autophagosomes, which fuse with...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-03 | PXD020359 | Pride
Autophagy Atg9 Vesicles Yeast 
ProteomicsTranscriptomic and proteomic analysis reveals a core Atg9 interactome in the regulation of yeast macroautophagy
In Saccharomyces cerevisiae, Atg9 is an important AuTophaGy-related (Atg) protein, plays critical roles in regulating macroautophagy/autophagy, and physically interacts with hundreds of proteins. How Atg9 interacting partners are synergistically orchestrated in autophagy are unclear. Here, we conduc...
ORGANISM(S): Saccharomyces Cerevisiae 
2019-01-19 | PXD012458 |
ProteomicsRNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
Autophagy is an evolutionary ancient mechanism that sequesters substrates for degradation within autolysosomes. The process is driven by many autophagy-related (ATG) proteins, including the core members ATG9 and ATG16. Here, we applied RNAseq and tandem mass tag (TMT) proteomic approaches to identif...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2021-06-15 | PXD023730 | Pride
Atg9 Rnaseq Parallel reaction monitoring (prm) Tandem mass tag (tmt) Autophagy Proteome Atg16 Dictyostelium discoideum 
ProteomicsAtg9 resides on a unique population of small vesicles in presynaptic nerve terminals
In neurons, autophagosomes are mainly initiated in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane lipids which requires small vesicles containing Atg9, a lipid scramblase essential for autophagocytosis. Here, we show that Atg...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-17 | PXD041702 | Pride
Neurons Immunoisolation Atg9 
TranscriptomicsRNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
Purpose: Global survey of the transcriptome and comparison to the proteome in autophagy-deficient strains of D. discoideum. Results: Our RNAseq analysis of ATG9‾, ATG16‾ and ATG9‾/16‾ cells revealed major transcriptional changes in a large number of genes in comparison to AX2. Conclusions: Our study...
ORGANISM(S): Dictyostelium discoideum 
2021-05-19 | GSE162070 | GEO
GenomicsRNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
PRJNA680492 | ENA
UnknownMec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stress.
Not available
S-EPMC11831128 | biostudies-literature
UnknownThe phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions.
Not available
S-EPMC4422124 | biostudies-literature
UnknownNew Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia.
Not available
S-EPMC11877618 | biostudies-literature
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