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TranscriptomicsTranscription profiling of human adult T cell leukemia cell lines to investigate the biological pathways of Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma (Mitsiades e...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-12287 | biostudies-arrayexpress
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-12257 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of cytokines and its receptors in primary murine lymphoblastoid cells (pML cells)
Transcriptional profiling of cytokines and its receptors in primary murine lymphoblastoid cells (pML cells), which are lymphomatous cells from HTLV-1 TAX transgenic mice. ATL is a T-cell malignancy caused by HTLV-I, and presents as an aggressive leukemia with characteristic widespread leukemic cell ...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17341 | biostudies-arrayexpress
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
ProteomicsER-shaping Atlastin proteins differentially contribute to flavivirus replication and assembly
Flaviviruses, including Dengue virus (DV) and Zika virus, extensively remodel the cellular endomembrane network to generate replication organelles that promote viral genome replication and virus production. However, it remains unclear how these membranes and associated cellular proteins act during t...
ORGANISM(S): Homo sapiens (Human) 
2019-10-17 | PXD014639 | Pride
Atl-2 Atlastin Atl-3 Proteome Ap-lc-ms/ms 
TranscriptomicsExpression profiling by array in ATLL
Previously, we have shown that an AP-1 family member Fra-2, which is hardly expressed in normal mature T cells, is consistently over-expressed in adult T-cell leukemia/lymphoma (ATLL), and together with JunD, upregulates CCR4 and many other genes including proto-oncogenes c-Myb, MDM2, Bcl-6, and SOX...
ORGANISM(S): Homo sapiens 
2013-05-16 | E-GEOD-38021 | biostudies-arrayexpress
Genomicsf19604a4-840d-4c86-b83b-64ca929f9757 - samples
Whole exome sequencing (WES) data of peripheral blood mononuclear cells (PBMCs) obtained from 2 ATL patients (3 samples).
EGAD00001007016 | EGA
Methylation profilingDNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant tra...
ORGANISM(S): Homo sapiens 
2023-05-03 | GSE189602 | GEO
TranscriptomicsDNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Affymetrix]
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant tra...
ORGANISM(S): Homo sapiens 
2023-05-03 | GSE189603 | GEO
TranscriptomicsBioligical pathways of Hsp90 inhibitors in adult T cell leukemia cell lines
Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma (Mitsiades e...
ORGANISM(S): Homo sapiens 
2009-05-27 | GSE12287 | GEO
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