Sort   by:  
 Page size 
TranscriptomicsWhole genome gene expression profiling in CD4+ T-cells, FACS-sorted based on CADM1/CD7 expression levels, in Adult T-cell Leukemia-lymphoma (ATL) patients, HTLV-1 carriers, and in healthy volunteers.
CADM1 overexpresion and stepwise downregulation of CD7 in CD4+T-cells from ATL patients and HTLV-1 carriers accurately reflect the process of disease, i.e., oligoclonally and clonally exanding cells are accumulated in D (CADM1posCD7dim) and N (CADM1posCD7neg) populations, respectively. Moreover, gen...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-55851 | biostudies-arrayexpress
TranscriptomicsInfluence of ATL-type Helios overexpression or WT-Helios/Ikaros knockdown on gene expression profile in Jurkat cells
It has been known that aberrant isoforms of Ikaros family ptoteins are expressed in malignant cells. We identified that PBMC of ATL (acute T-cell leukemia) patients expresses different patterns of Helios isoforms compared with normal PBMC. In order to investigate the biological impact of ATL-type He...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-41796 | biostudies-arrayexpress
TranscriptomicsWhole genome gene expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted c...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33615 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted c...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-31629 | biostudies-arrayexpress
ProteomicsER-shaping Atlastin proteins differentially contribute to flavivirus replication and assembly
Flaviviruses, including Dengue virus (DV) and Zika virus, extensively remodel the cellular endomembrane network to generate replication organelles that promote viral genome replication and virus production. However, it remains unclear how these membranes and associated cellular proteins act during t...
ORGANISM(S): Homo sapiens (Human) 
2019-10-17 | PXD014639 | Pride
Atl-2 Atlastin Atl-3 Proteome Ap-lc-ms/ms 
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-12257 | biostudies-arrayexpress
TranscriptomicsInduction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells
The mechanism whereby IL-9 stimulated monocytes, promote proliferation of co-cultured ATL cells remains undefined. To obtain preliminary clues concerning this contribution, transcription profiles were obtained between monocytes derived from ATL patients and those derived from healthy donors as asses...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10789 | biostudies-arrayexpress
TranscriptomicsImmunomodulatory drugs (IMiDs)- or cereblon E3 ligase modulator (CELMoD)-induced growth suppression of Adult T-Cell Lymphoma/Leukemia (ATL) cells and the intrinsic rolls of cereblon for down-regulation of target proteins and their down-stream effectors II
Adult T-cell lymphoma/leukemia (ATL) is an aggressive subtype of leukemia/lymphoma caused by human T-cell leukemia virus type-1 (HTLV-1) and existing chemotherapy for ATL remains with extremely poor prognosis. Therefore, more effective therapeutic options are urgent needs for this disease. Since rec...
ORGANISM(S): Homo sapiens 
2024-02-15 | GSE221062 | GEO
TranscriptomicsImmunomodulatory drugs (IMiDs)- or cereblon E3 ligase modulator (CELMoD)-induced growth suppression of Adult T-Cell Lymphoma/Leukemia (ATL) cells and the intrinsic rolls of cereblon for down-regulation of target proteins and their down-stream effectors
Adult T-cell lymphoma/leukemia (ATL) is an aggressive subtype of leukemia/lymphoma caused by human T-cell leukemia virus type-1 (HTLV-1) and existing chemotherapy for ATL remains with extremely poor prognosis. Therefore, more effective therapeutic options are urgent needs for this disease. Since rec...
ORGANISM(S): Homo sapiens 
2024-02-15 | GSE221056 | GEO
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma ...
ORGANISM(S): Homo sapiens 
2009-05-27 | GSE12257 | GEO
Sort   by:  
 Page size