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ProteomicsATM interactome and analysis of its substrates
Study of ATM interactome and its substrates following pull-down with anti -pSQ/TQ antibody
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD032194 | Pride
Nlc-ms-ms Phosphorylated proteins Interactome 
ProteomicsROS-activated ATM-dependent phospho-signaling
ATM (ataxia-telangiectasia mutated) protein plays a central role in phosphorylating a network of proteins in response to DNA double strand breaks. These phosphorylated proteins function in signalling pathways designed to maintain the stability of the genome and minimize the risk of disease by contro...
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD002850 | Pride
Reactive oxygen species Atm Fibroblast Phosphoproteomics 
UnknownReactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen.
Not available
S-EPMC4813686 | biostudies-literature
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
ProteomicsATM promotes reversed fork processing during DNA interstrand cross-link repair
During replication-coupled DNA interstrand cross-link (ICL) repair, fork reversal is thought to enable the Fanconi anemia (FA) pathway to resolve the ICL through nucleolytic incisions. Subsequent fork restoration then allows nascent DNA strand extension past the lesion. Although these fork remodelin...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-08-25 | PXD071242 | Pride
Fork reversal Interstrand cross-link Exo1 Icl repair Pp2a Fanconi anemia pathway Dna2 Atm Fork restoration Orbitrap astral mass spectrometer Wrn 
UnknownProfiling of UV-induced ATM/ATR signaling pathways.
Not available
S-EPMC2148387 | biostudies-literature
UnknownMRE11 UFMylation promotes ATM activation.
Not available
S-EPMC6486557 | biostudies-literature
UnknownStructure of the intact ATM/Tel1 kinase.
Not available
S-EPMC4894967 | biostudies-literature
UnknownStructure of the human dimeric ATM kinase.
Not available
S-EPMC4889239 | biostudies-literature
UnknownATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2).
Not available
S-EPMC5056966 | biostudies-literature
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