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ProteomicsCyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair
Ubiquitination is a crucial post-translational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionising radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and non-homologous end joining (NHEJ) in its a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051841 | Pride
Microhomology-mediated end joining And cancer Ionising radiation Dna damage repair Dna damage response Dna double strand breaks Exo1 Ubiquitination Single strand annealing Cell cycle Cyclin f 
ProteomicsExonuclease-1 interactome and phosphorylation sites
To help shedding light on regulatory aspects of DNA repair and remodeling pathways in which EXO1 participates and to help revealing novel cellular processes in which EXO1 is involved, we set out to identify proteins interacting with EXO1. Both a small-scale approach and a comprehensive analysis of t...
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD002780 | Pride
Human Exo1 Phosphorylation Affinity tag purification 
GenomicsRole of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
PRJNA760318 | ENA
ProteomicsPull-down of Exo1-TAP from yeast meiotic cells and analysis of phosphorylated residues
Exo1 tagged with the TAP sequence was pulled down from synchronous ndt80∆ meiotic cells after induction of the CDC5 kinase at t = 8 h 15 in meiosis (1 h 15 after CDC5 induction), in order to identify its phosphorylated residues
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-11-06 | PXD014185 | Pride
Crossover Meiosis Recombination Mutlgamma 
OtherRole of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
DNA damage response pathways rely extensively on nuclease activity to process DNA intermediates. Exonuclease 1 (EXO1) is a pleiotropic evolutionary conserved DNA exonuclease. In mammals, it is involved in various DNA repair pathways, replication, antibody diversification, and meiosis. But, whether E...
ORGANISM(S): Mus musculus 
2022-07-11 | GSE183344 | GEO
GenomicsEXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA
EXO1 has a structural role to promote the MLH1-MLH3 nuclease complex to process meiotic recombination intermediates into crossovers. The authors demonstrate that EXO1 function depends on conserved interactions with the MSH4 subunit of MSH4-MSH5, the MLH1 subunit of MLH1-MLH3, and DNA.
PRJEB88381 | ENA
GenomicsMechanism of in vivo activation of the MutL-Exo1 complex for meiotic crossover formation
Mechanism of in vivo activation of the MutL-Exo1 complex for meiotic crossover formation
PRJNA549945 | ENA
GenomicsMechanism of in vivo activation of the MutLgamma-Exo1 complex for meiotic crossover formation
Mechanism of in vivo activation of the MutLgamma-Exo1 complex for meiotic crossover formation
PRJNA549269 | ENA
UnknownDNA duplex recognition activates Exo1 nuclease activity.
Not available
S-EPMC6663874 | biostudies-literature
UnknownMolecular interactions of human Exo1 with DNA.
Not available
S-EPMC100345 | biostudies-literature
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