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ProteomicsTotal and phosphoproteome analysis of effects of topoisomerase 1 and ATR inhibitors in small cell lung cancer nuclei
Total and phosphoproteome analysis of effects of topoisomerase 1 (SN-38) and ATR (M1774) inhibitors in small cell lung cancer. Experiments performed in nuclear extract. See MetaData for more information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-21 | MSV000091336 | MassIVE
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
TranscriptomicsTranscription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants
Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.
ORGANISM(S): Arabidopsis thaliana 
2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human neuroblastoma cell lines treated with the ATR inhibitor BAY 1895344
To characterize the downstream gene expression response following ATR inhibition, we performed RNA-Seq after treatment of CLB-BAR and CLB-GE neuroblastoma cells with 50 nM of the ATR inhibitor BAY 1895344 for 24h and 48h
ORGANISM(S): Homo sapiens 
2021-10-21 | E-MTAB-10603 | biostudies-arrayexpress
TranscriptomicsRNA-seq of neuroblastoma mice models after treatment with the ATR inhibitor BAY 1895344
To understand the in vivo transcriptomic response to ATR inhibition, RNA-Seq was performed after treatment of 2 previously developed neuroblastoma mouse models (Alk-F1178S;Th-MYCN and Rosa26_Alkal2;Th-MYCN; see Borenas et al., EMBO J, 2021) with the ATR inhibitor BAY 1895344.
ORGANISM(S): Mus musculus 
2021-10-21 | E-MTAB-10616 | biostudies-arrayexpress
ProteomicsComparative phosphoproteomic analysis of HeLa cells in response to etoposide or to a combination of etoposide and the ATR inhibitor VE821
To investigate the regulation of protein phosphorylation during the DNA damage response and the role of ATR kinase activity, we performed a comparative phosphoproteomic analysis of HeLa cells treated with etoposide alone or in combination with the ATR inhibitor VE821. Etoposide is a topoisomerase II...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067042 | Pride
Phosphoproteomics Etoposide Atr inhibitor 
ProteomicsATR-mediated Proteome Remodeling is a Major Determinant of Homologous Recombination Capacity in Cancer Cells
DMSO or 5uM ATR inhibitor(VE-821) were treated for 8 days on U2OS cells prior to anlaysis.
ORGANISM(S): Homo sapiens (Human) 
2018-07-17 | PXD010223 | Pride
Atr inhibitor 
ProteomicsPhospho-proteomics analysis of ATR inhibitor responses in sensitive and resistant human breast cancer cells
To search in an unbiased manner for the specific mechanisms causing differential ATRi sensitivity, we performed total and phosphoproteomic analyses using tandem mass tagging (TMT) mass spectrometry. Extracted proteins were compared between three sensitive and three resistant human breast cancer cell...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD061444 | Pride
Atr  phospho-proteomics  tmt 
GenomicsHigh origin firing capacity leads to ATR inhibitor sensitivity via increased replication catastrophe
High origin firing capacity leads to ATR inhibitor sensitivity via increased replication catastrophe
PRJEB85428 | ENA
ProteomicsATR inhibition enables complete tumour regression in ALK-driven NB mouse models
High-risk neuroblastoma (NB) often involves amplification of the neural MYC (MYCN) oncogene as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes such as MYCN and ALK result in increased replication str...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027187 | Pride
Neuroblastoma Atr inhibitor Phosphorylation Alk 
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