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MetabolomicsFatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease
Not available
ORGANISM(S): Mus musculus 
ST000878 | MetabolomicsWorkbench
TranscriptomicsRole of sex chromosome complement in autosomal gene expression
It has generally been assumed that most differences between males and females are due to developmental and hormonal differences between the sexes. Here we investigate the contribution of sex chromosomal complement to such sexual dimorphisms. These genome-wide transcription profiling showed that the ...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-21822 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of autosomal sex differences in human DNA methylome
Sex difference had been implicated in pathophysiology and prognosis of common diseases, such as acute lymphoblastic leukemia and coronary heart disease. It is well known that the disease phenotype is shaped by the interaction between the environment, genome, and epigenome. The environmental and the ...
ORGANISM(S): Homo sapiens 
2011-08-21 | E-GEOD-23638 | biostudies-arrayexpress
TranscriptomicsGene expression in early phases of Autosomal Dominant Polycystic Kidney Disease
Little is known about the genes involved in the initial cyst formation and disease progression in autosomal dominant polycystic kidney disease (ADPKD). To uncover the genetic determinants and molecular mechanisms of ADPKD, we analyzed 4-point time-series DNA microarrays from Pkd1L3/L3 mice to genera...
ORGANISM(S): Mus musculus 
2008-12-28 | E-GEOD-13452 | biostudies-arrayexpress
TranscriptomicsExpression data from renal cysts of autosomal dominant polycystic kidney disease (ADPKD) patients
To elucidate the molecular pathways that modulate renal cyst growth in autosomal dominant polycystic kidney disease (ADPKD) Keywords: Disease state analysis We performed global gene profiling on renal cysts of different size (small cysts: less than 1 ml, n=5; medium cysts: between 10-25 ml, n=5; lar...
ORGANISM(S): Homo sapiens 
2009-08-14 | E-GEOD-7869 | biostudies-arrayexpress
ProteomicsLC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse
This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant al...
ORGANISM(S): Mus Musculus 
2025-02-05 | PXD060501 |
TranscriptomicsAutosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia
Sakha M-bM-^@M-^S an area connecting South and Northeast Siberia M-bM-^@M-^S is significant for understanding the history of peopling of Northeast Eurasia and the Americas. Previous studies have shown a genetic contiguity between Siberia and East Asia and the key role of South Siberia in the coloniz...
ORGANISM(S): Homo sapiens 
2013-06-26 | E-GEOD-46828 | biostudies-arrayexpress
GenomicsDosage responses of aneuploid autosomal chromosomes (DNA-Seq)
Dosage responses of aneuploid autosomal chromosomes (DNA-Seq)
PRJEB98355 | ENA
ProteomicsAutosomal Dosage Compensation in Aneuploidy and Cancer Is Mediated by Transcriptional Bursting Regulation
Aneuploidy, resulting from partial (segmental) or complete chromosomal gains or losses, is generally detrimental to organismal fitness, but is also associated with tumorigenicity. While sex chromosome aneuploidies are well-tolerated via dedicated allelic dosage compensation mechanisms, the existence...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-29 | PXD068580 | Pride
Aneuploidy Autosomal Mus musculus Dosage compensation 
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
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