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ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
TranscriptomicsGlobal transcriptome analysis reveals differences between embryonic and adult dorsal root ganglion axonal mRNAs that are implicated in axonal growth and pain
Local protein synthesis in sensory neuron axons is necessary for axonal regeneration with the efficiency of regeneration decreasing with age. Because the full repertoire of transcripts in embryonic and adult rat sensory axons is unknown we asked how the pool of mRNAs dynamically changes during age...
ORGANISM(S): Rattus norvegicus 
2010-11-23 | E-GEOD-22638 | biostudies-arrayexpress
ProteomicsVAMP7 KO and ATG5 KO in axonal growth
VAMP7 is involved in autophagy and in exocytosis mediating neurite growth, two yet unconnected cellular pathways. Here we found that nutrient restriction and activation of autophagy stimulated axonal growth while inhibition led to multiple axons. VAMP7 KO neuronal cells showed impaired whereas ATG5 ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-29 | PXD020502 | Pride
Secretion Neurons Vamp7 Amphisomes Axonal growth 
TranscriptomicsAxonal mRNA in human embryonic stem cell derived neurons
The identification of axonal mRNAs in model organisms has led to the discovery of many axonally translated proteins required for axon guidance and injury response. The extent to which these axonal mRNAs are conserved in humans is unknown. Here we report on the axonal transcriptome of glutamatergic n...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-84975 | biostudies-arrayexpress
ProteomicsProteomic analysis of growth cones from WT and HD mice
Although Huntington’s disease (HD) is a late onset neurological condition, studies suggest a developmental contribution to its adult manifestations. Imaging studies in presymptomatic HD gene carriers revealed early alterations in white matter tract with a marked defect in the corpus callosum. This t...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-08 | PXD023885 | Pride
Growth cone Huntington’s disease Lc-ms/ms 
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
ProteomicspSILAC-SP3 of RGC axonal growth cones
To form operative neuronal networks neurons connect to their synaptic partners by axonal outgrowth guided by the movement of the axon tip, a specialized structure known as the growth cone (GC), which travels along stereotypical paths by sensing extracellular guidance cues. Interestingly, GCs contain...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2018-08-10 | PXD005469 | Pride
Axon Psilac 
TranscriptomicsSprouting transcriptome in cortical neurons: young
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24440 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons: aged
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24441 | biostudies-arrayexpress
TranscriptomicsRNA sequence reveals mouse retinal transcriptome changes early after axonal injury
Purpose: The purpose of this study was　to use RNA-seq to investigate the molecular mechanisms of damage in the early stages of the response to axonal injury, before the onset of RGC death. Methods: 12-week-old wild-type (WT) mice were used in this study. The experiment group underwent an optic nerve...
ORGANISM(S): Mus musculus 
2014-02-21 | E-GEOD-55228 | biostudies-arrayexpress
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