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TranscriptomicsTranscription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection
Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data sugges...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-14366 | biostudies-arrayexpress
TranscriptomicsModulation of gene expression in U251 glioblastoma cells by binding of mutant p53 to intronic and intergenic sequences
Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act a...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13991 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of inducible overexpression of Arabidopsis meristem regulators by AlcR / AlcA system in continuous light
Inducible overexpression of Arabidopsis meristem regulators by AlcR / AlcA system. Plants harboring 35S::AlcR/AlcA::GOI (GUS control, LEAFY, SHOOTMERSTEMLESS, WUSCHEL)constructs were grown in continous light for 12 days and induced with 1% Ethanol. After 12h of EtOH treatment, seedlings were dissect...
ORGANISM(S): Arabidopsis thaliana 
2006-01-01 | E-MEXP-432 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain from mice with ischemia of the right common carotid artery or sham treated and then exposed to hypoxic conditions
Animals were anaesthetized with halothane (4% in 70% N2O: 30% O2). A small incision was made in the neck and the right common carotid artery was exposed and ligated with 4-0 surgical silk in three separate locations. The incision was closed, and the animal allowed to recover with access to food an...
ORGANISM(S): Mus musculus 
2007-11-13 | E-MEXP-1253 | biostudies-arrayexpress
TranscriptomicsHigh- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis
In Bacillus subtilis and its relatives carbon catabolite control, a mechanism enabling to reach maximal efficiency of carbon and energy sources metabolism, is achieved by the global regulator CcpA (carbon catabolite protein A). CcpA in a complex with HPr-Ser-P (seryl-phosphorylated form of histidine...
ORGANISM(S): Bacillus subtilis 
2012-08-13 | E-GEOD-35154 | biostudies-arrayexpress
TranscriptomicsADAR1-mediated A-to-I RNA editing is essential for erythropoiesis [RNA-seq]
Purpose: RNA editing by ADAR1 is essential for hematopoietic development. The goals of this study were firstly, to identify ADAR1-specific RNA-editing sites by indentifying A-to-I (G) RNA editing sites in wild type mice that were not edited or reduced in editing frequency in ADAR1 deficient murine e...
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-71042 | biostudies-arrayexpress
TranscriptomicsMusashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA binding protein that can act as a transla...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29432 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of human retinal detachment (RD) reveals both inflammation and photoreceptor death
We have used surgical specimens to perform a differential analysis of the transcriptome of human retinal tissues following detachment. Data analysis reveals major involvement of the immune response in the disease and interindividual variation was monitored to unravel a second crucial aspect of the p...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28133 | biostudies-arrayexpress
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