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MetabolomicsMicrobiota-derived metabolites act as ecological effectors of colonization resistance against Salmonella Enteritidis

Colonization resistance is a fundamental ecological function of the gut microbiota that limits the expansion of enteric pathogens. Yet, the microbial effectors linking ecosystem homeostasis to pathogen control remain poorly understood. Here, we demonstrate that Salmonella Enteritidis (S. Enteriti...

2026-08-31 | MTBLS15505 | MetaboLights
TranscriptomicsTranscriptomes and differential gene expression analysis of the Arabidopsis cells that received type-III effectors delivered by Xanthomonas campestris pv. Campestris (Xcc) bacterial mutants
Due to low numbers and poor accessibility of host cells that are targeted for effector delivery, the actual biological functions of most effectors remain elusive. Here, we developed a novel Isolation Nuclei TArgeted by Bacterial Effectors (INTABE) system, which facilitates selectively recovering nuc...
ORGANISM(S): Arabidopsis thaliana 
2022-10-22 | E-MTAB-10280 | biostudies-arrayexpress
TranscriptomicsHost transcriptional reprogramming across diverse strains of the rice bacterial leaf streak pathogen Xanthomonas oryzae pv.oryzicola
We performed RNA-Seq of leaves of Oryza sativa L. ssp. japonica cv. Nipponbare 48 hours after inoculation with 10 geographically diverse strains of Xanthomonas oryzae pv. oryzicola, the causal agent of bacterial leaf streak. Results provide insight into the molecular basis of bacterial leaf streak, ...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-01 | E-GEOD-67588 | biostudies-arrayexpress
GenomicsDNA methylation profiling and analysis of differentially methylated regions (DMRs) of the Arabidopsis cells that received type-III effectors delivered by Xanthomonas campestris pv. Campestris (Xcc) bacterial mutants
Due to low numbers and poor accessibility of host cells that are targeted for effector delivery, the actual biological functions of most effectors remain elusive. Here, we developed a novel Isolation Nuclei TArgeted by Bacterial Effectors (INTABE) system, which facilitates selectively recovering nuc...
ORGANISM(S): Arabidopsis thaliana 
2022-10-22 | E-MTAB-10281 | biostudies-arrayexpress
TranscriptomicsA Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate IFN-s...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-GEOD-26414 | biostudies-arrayexpress
ProteomicsSerine ubiquitination of SNAREs generates bacterial vacuoles and prevents their lysosomal fusion
Here we show that Legionella SidE effectors mediate phosphoribosyl-linked serine ubiquitination (PR-Ub) of the autophagic SNARE proteins STX17 and SNAP29. On the one hand, PR-Ub modification of STX17 enhances its interaction with ATG14L, which drives the recruitment of ER membranes to the bacterial ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD058184 | Pride
Legionella pneumophila Xenophagy Syntaxin17 Ubiquitin Autophagy 
TranscriptomicsSecreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila [exp2]
The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires’ Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm system ...
ORGANISM(S): Mus musculus 
2011-01-08 | E-GEOD-26490 | biostudies-arrayexpress
ProteomicsArg-GlcNAcylation of GshB, An intra-bacterial activity for a T3SS effector
Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins directly into infected host cells. A subset of these injected protein ‘effectors’ are enzymes that modify the structure and inhibit the function of human prote...
ORGANISM(S): Escherichia coli 
2020-01-14 | PXD015752 | Pride
Citrobacter rodentium Ehec Nleb Glycosylation Epec Effectors 
TranscriptomicsSecreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila
This SuperSeries is composed of the following subset Series: GSE26473: Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila [exp1] GSE26490: Secreted bacterial effectors that inhibit host protein ...
ORGANISM(S): Mus musculus 
2011-01-08 | E-GEOD-26491 | biostudies-arrayexpress
ProteomicsThe E. coli type III secreted effectors NleB and EspL interact with the microtubule associated protein ensconsin to disrupt vesicle trafficking, part 1
Enteropathogenic and enterohaemorrhagic E. coli (EPEC and EHEC) translocate a set of type III effector proteins into host cells that are critical for bacterial virulence. These effectors subvert normal host pathways by interacting with a variety of targets within the cell, but the binding partners ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2016-12-22 | PXD002933 | Pride
Human E. coli Effector Host-pathogen 
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