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ProteomicsInfluenza A hemagglutinin glycoproteomics similarity
Influenza A virus (IAV) mutates rapidly, preventing a single seasonal vaccine from targeting more than one strain, and year-to-year vaccine effectiveness is low. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hem...
ORGANISM(S): Viruses Homo sapiens (Human) Gallus gallus (Chicken) 
2020-07-03 | PXD018920 | Pride
Glycosylation Influenza a Lc-ms Similarity Glycopeptides 
ProteomicsImproving statistical certainty of glycosylation similarity between influenza A virus variants using data-independent acquisition mass spectrometry
The amino acid sequences of immunodominant domains of hemagglutinin (HA) on the surface of influenza A virus (IAV) evolve rapidly, producing viral variants. HA mediates receptor recognition, binding and cell entry, and serves as the target for IAV vaccines. Glycosylation, a post-translational modifi...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) Gallus gallus (Chicken) 
2022-09-24 | PXD029700 | Pride
Influenza Dia Glycoproteomics Mass spectrometry Glycosylation similarity Hemagglutinin 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD027425 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
GenomicsThe Ovarian Cancer Association Consortium Data Access Committee
Data Access Committee EGAC00001000616
EGAC00001000616 | EGA
UnknownSeroprevalence of Japanese encephalitis virus-specific antibodies in Australia following novel epidemic spread: protocol for a national cross-sectional study.
Not available
S-EPMC10860057 | biostudies-literature
UnknownRandomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy.
Not available
S-EPMC10115230 | biostudies-literature
GenomicSporadic Autism Exomes Reveal a Highly Interconnected Protein Network of De Novo Mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482 | dbGaP
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