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ProteomicsDeposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses
Mutations in histone H3.3-encoding genes causing mutant histone tails are associated with specific cancers such as pediatric glioblastomas (H3.3-G34R/V) and giant cell tumor of the bone (H3.3-G34W). The mechanisms by which these mutations promote malignancy are not completely understood. Here we sho...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD047223 | Pride
H3.3 Onco-histone Dna repair Immune response G34w Cgas/sting 
ProteomicsID3 Deficiency Alters Chromatin Accessibility at DSB Sites and Enhances Vulnerability to HDAC Inhibition
The inhibitor of DNA-binding 3 (ID3) plays a crucial role in DNA double-strand break (DSB) repair. We previously reported that ID3 loss reduced chromatin accessibility at DNA repair gene promoters, yet its exact role in DNA repair via chromatin regulation remained elusive. Using the AID-DIvA cell sy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD069605 | Pride
Id3 Chromatin accessibility Hdac Dsb Inhibition 
UnknownGarlic and allopurinol alleviate the apoptotic pathway in rats' brain following exposure to fipronil insecticide.
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S-EPMC10014746 | biostudies-literature
UnknownBioactive phenolics fraction of Hedera helix L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress.
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S-EPMC9130539 | biostudies-literature
UnknownEfficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Microwave Irradiation.
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S-EPMC9260951 | biostudies-literature
UnknownAcetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways.
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S-EPMC10066216 | biostudies-literature
UnknownAnalysis of four long non-coding RNAs for hepatocellular carcinoma screening and prognosis by the aid of machine learning techniques.
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S-EPMC11604705 | biostudies-literature
UnknownPlasma long non-coding RNAs as biomarkers for bone marrow infiltration and stage in diffuse large B-cell lymphoma.
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S-EPMC11483759 | biostudies-literature
UnknownEdaravone and obeticholic acid protect against cisplatin-induced heart toxicity by suppressing oxidative stress and inflammation and modulating Nrf2, TLR4/p38MAPK, and JAK1/STAT3/NF-κB signals.
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S-EPMC11329704 | biostudies-literature
UnknownOral cancer knowledge and practice among medical students: A cross-sectional study during the Syrian crisis.
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S-EPMC9142404 | biostudies-literature
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