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ProteomicsQuantitative analysis of the proteome response to the histone deacetylase inhibitor (HDACi) Vorniostat in Niemann-Pick Type C1 disease
Niemann-Pick type C (NPC) disease is an inherited, progressive neurodegenerative disorder principally caused by mutations in the NPC1 gene. NPC disease is characterized by the accumulation of unesterified cholesterol in the late endosomes (LE) and lysosomes (LE) (LE/LY). Vorinostat, a histone deacet...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD006005 | Pride
Proteomics Niemann-pick type c1 (npc1) disease npc1 Tmt Tandem mass tag Lipa Quantitative proteomics Lysosomal acid lipase Vorinostat 
OtherQuantitative proteomics of human NPC1I1061T (sic) mutant fibroblasts provides insights into the pathogenesis of Niemann-Pick Type C disease.
Data from ProteomeXchange, PXD ID: PXD001938. Experiment: WTvsI1061T_TMT_inj01, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Apr 14 . From the Abstract: {{i}} In our study, an isobaric labeling based quantitative analysis of proteome of NPC1I1061T (sic) primary fibroblasts w...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014822 | GPMDB
Resource Reanalysis 
ProteomicsCFTR interactome
The uploaded files are the RAW files used to generate the CFTR interactome dataset. The raw data were searched with ProLuCID against the human IPI database version 3.23 and search results were filtered with DTASelect 2.1.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-13 | MSV000079235 | MassIVE
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