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TranscriptomicsRNA-seq analysis of vorinostat-resistant HCT116 cells following gene knockdown of GLI1 or PSMD13 with or without vorinostat treatment
Transcriptome analysis was conducted on vorinostat resistant HCT116 cells (HCT116-VR) upon knockdown of potential vorinostat resistance candidate genes in the presence and absence of vorinostat. Potential vorinostat resistance candidate genes chosen for this study were GLI1 and PSMD13, which were i...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-57871 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment
Gene Expression Profiling of a Mouse Xenograft Model of â??Triple-Negativeâ?? Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few...
ORGANISM(S): Homo sapiens 
2009-10-27 | E-GEOD-18544 | biostudies-arrayexpress
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
ProteomicsDevelopment and characterization of vorinostat resistant cutaneous T cell lymphoma cells
Vorinostat is the very first approved inhibitor of histone deacetylase, widely used in many countries for the treatment of primary/ persistent cutaneous T cell lymphoma (CTCL). However, problems associated with intrinsic and acquired resistance to vorinostat present a significant challenge to therap...
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD026689 | Pride
Erk Vorinostat resistance Silac proteomics Rnaseq analysis 
TranscriptomicsComprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate
Transcriptional profiling of NK cell lines (NKL & NKYS) with DMSO or vorinostat
ORGANISM(S): Homo sapiens 
2013-01-24 | E-MTAB-1410 | biostudies-arrayexpress
ProteomicsQuantitative analysis of the proteome response to the histone deacetylase inhibitor (HDACi) Vorniostat in Niemann-Pick Type C1 disease
Niemann-Pick type C (NPC) disease is an inherited, progressive neurodegenerative disorder principally caused by mutations in the NPC1 gene. NPC disease is characterized by the accumulation of unesterified cholesterol in the late endosomes (LE) and lysosomes (LE) (LE/LY). Vorinostat, a histone deacet...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD006005 | Pride
Proteomics Niemann-pick type c1 (npc1) disease npc1 Tmt Tandem mass tag Lipa Quantitative proteomics Lysosomal acid lipase Vorinostat 
TranscriptomicsThe Pelvic Radiation and Vorinostat (PRAVO) Study - Histone Deacetylase Inhibitor Activity
The study objective was to propose molecular mechanisms of action of the histone deacetylase inhibitor vorinostat. In the PRAVO phase 1 study, patients that were scheduled to receive pelvic palliative radiation to 30 Gy in 3-Gy fractions for gastrointestinal carcinoma, were enrolled onto four sequen...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-46703 | biostudies-arrayexpress
GenomicsCut&Run SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
Cut&Run SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
PRJNA915081 | ENA
GenomicsMARS-seq on SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
MARS-seq on SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
PRJNA915084 | ENA
GenomicsVorinostat treatment of PPS-ICBR cells
Vorinostat treatment of PPS-ICBR cells
PRJNA845791 | ENA
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