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UnknownA self-powered and self-monitoring ultra-low frequency wave energy harvester for smart ocean ranches.
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S-EPMC11389548 | biostudies-literature
GenomicsGenome wide binding sites of Smad3 and JMJD3 in neural stem cells
Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFM-NM-2 pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promo...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-36673 | biostudies-arrayexpress
GenomicsRNAPII progression through H3K27me3 enriched gene bodies require JMJD3 HDM activity
Several signaling pathways require JMJD3 binding to promoters to activate the expression of target genes. Despite the known H3K27me3 demethylase activity of JMJD3 the transcriptional coactivator mechanism remains unclear. Here we reveal that JMJD3 promotes transcription of TGFb responsive genes thro...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-38269 | biostudies-arrayexpress
TranscriptomicsThe MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype
Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosin...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36426 | biostudies-arrayexpress
TranscriptomicsThe role of nicotinamide phosphoribosyltransferase (Nampt) in hippocampal neural stem/progenitor cells
Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age, but the molecular mechanisms responsible for these declines remain unclear. Here we show that levels of NAD+ and nicotinamide phosphoribosyltransferase (Nampt), ...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-49784 | biostudies-arrayexpress
TranscriptomicsA Distinct Reactive Oxygen Species Profile confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Aims: We explore the role of elevated O2-:H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers. Results: We observed that elevated O2-:H2O2 ratio conferred enhanced resistance in GPCs, and depletion of t...
ORGANISM(S): Homo sapiens 
2013-03-13 | E-GEOD-32335 | biostudies-arrayexpress
TranscriptomicsIdentification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)
Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an or...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-16805 | biostudies-arrayexpress
TranscriptomicsComparison study of glioma stem cells and adult human neural stem cells
Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to...
ORGANISM(S): Homo sapiens 
2013-07-27 | E-GEOD-31262 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing for cancer stem cell properties in MCF-7 cells with knocked down CD24
CD24 is the one of cell surface protein that anchored via glycosyl phosphatidylinositol that links to cell surface and modulates growth and differentiation signal many of cell types. A small population of cells, namely M-bM-^@M-^XCancer Stem Cells (CSCs)M-bM-^@M-^Y, charges highly aggressive and met...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-61917 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal duodenal enteroids grown in EGF and/or NRG1
The purpose of this study was to interrogate the role of EGF-family ligands, in particular Epidermal Growth Factor (EGF) and Neuregulin 1 (NRG1), as human intestinal stem cell niche factors. An established duodenal enteroid line derived from a 20.2 week post conception biological specimen was expose...
ORGANISM(S): Homo sapiens 
2020-12-10 | E-MTAB-9720 | biostudies-arrayexpress
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