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Genomics
Whole stool from Alcohol Dependent participants during detoxification
PRJNA575744 | ENA
TranscriptomicsTranscriptome Profiling and Sequencing of differentiated Human Hematopoietic Stem cells Reveal Lineage Specific Expression and Alternative Splicing of Genes
Hematopoietic differentiation is strictly regulated by complex network of transcription factors that are controlled by ligands binding to cell surface receptors. Disruptions of the intricate sequences of transcriptional activation and suppression of multiple genes cause hematological diseases, such...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-29989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors
Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cel...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in lineage specific hematopoiesis
MicroRNA plays a critical role in a wide variety of biological processes and regulate genes associated with different biological processes such as development, proliferation, apoptosis, stress response, and tumourigenesis. Profiling miRNA expression during differentiation of embryonic stem cells wil...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-35532 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of THP-1 cells reveals nitric oxide activation of Erk regulates the stability and translation of mRNA transcripts containing CU-rich elements
Nitric oxide (NO) can stabilize mRNA by activating p38 mitogen-activated protein kinase (MAPK). Here, transcript stabilization by NO was investigated in human THP-1 cells using microarrays. After LPS pre-stimulation, cells were treated with actinomycin D and then exposed to NO without or with the p3...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4228 | biostudies-arrayexpress
TranscriptomicsCaloric Restriction in Leptin Deficiency Worsens Myocardial Steatosis
Caloric Restriction in Leptin Deficiency Worsens Myocardial Steatosis: Failure to Upregulate PPAR gamma and Thermogenic Glyecrolipid/Fatty Acid Cycling Growing evidence supports an anti-lipotoxic role for leptin in preventing inappropriate peripheral tissue lipid deposition. Obese, leptin deficien...
ORGANISM(S): Mus musculus 
2011-04-29 | E-GEOD-16790 | biostudies-arrayexpress
TranscriptomicsCooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24869 | biostudies-arrayexpress
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