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ProteomicsIdentification of CDC20/CDC20B partners in HEK cells demonstrates that CDC20, but not CDC20B, interacts with multiple APC/C components
Multiciliated cells (MCCs) harbour dozens to hundreds of motile cilia, which beat in a synchronized and directional manner, thus generating hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation critically depends on the synthesis and release of numerous centrioles b...
ORGANISM(S): Homo sapiens (Human) 
2019-04-03 | PXD010629 | Pride
Motile cilia Deuterosome Centriole Plk1 Cdc20b Separase Cdc20 Cell cycle Hek cells 
UnknownPateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells.
Not available
S-EPMC4712605 | biostudies-literature
TranscriptomicsTranscriptomic impact of microRNAs-449 or microRNAs-34 overexpression in proliferating human airway epithelial cells
We used microarrays to detail the global programme of gene expression that occurs in response to miR-449 or miR-34 overexpression in proliferating HAECs. Each donors were transfected with pre-miR-Negative control, pre-miR-449a and pre-miR-449b. The donors 3 and 4 were morever transfected with pre-mi...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22143 | biostudies-arrayexpress
UnknownHigh throughput error corrected Nanopore single cell transcriptome sequencing.
Not available
S-EPMC7423900 | biostudies-literature
TranscriptomicsIdentification of s-RNYs targets in bone marrow-derived macrophages
Bone marrow-derived macrophages (BMDMs) were collected from 4 C57BL/6J males and transfected with siRNAs against the terminal loop of mouse RNYs and control. 48 hr after transfection, the total RNA was isolated by using RNAeasy kit (Qiagen) and mRNA profiling was performed on Agilent Sureprint whole...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-47518 | biostudies-arrayexpress
TranscriptomicsRole of miR-125b in B-cell acute lymphoblastic leukemia (B-ALL)
B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA miR-125b-1 is over-expressed in B-ALL cases wi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30647 | biostudies-arrayexpress
TranscriptomicsThe 3’UTR of FMR1 mRNA is a target of miR101, miR129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.
While FMR1 is silenced in Fragile X syndrome (FXS), its expression is elevated (2-8 fold) in premutated individuals. These people may develop the Fragile X-associated Tremor Ataxia Syndrome (FXTAS), a late onset neurodegenerative disorder characterized by ataxia and parkinsonism. In addition, people...
ORGANISM(S): Mus musculus 
2013-03-07 | E-GEOD-43670 | biostudies-arrayexpress
TranscriptomicsMicroRNA signature during the time course of regeneration of the human airway mucociliary epithelium
The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). The airway mucociliary epithelium is consituted of three main cell types : ciliated cells, secretory cells and basal...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22141 | biostudies-arrayexpress
UnknownNovel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.
Not available
S-EPMC6826037 | biostudies-literature
TranscriptomicsmiRNAs high throughput sequencing profiling of basals cells and columnar cells
The airway mucociliary epithelium is consituted of three main cell types : columnar ciliated plus secretory cells and basal cells. Columnar cells are represented by a great majority of ciliated cells. We used Cell sorting by FACSaria to separate basal cells from ciliated and secreting columnar cell...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22145 | biostudies-arrayexpress
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