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TranscriptomicsMulticilin drives centriole biogenesis via E2f proteins
Biochemistry suggests e2f4 forms a complex with the coiled-coiled protein multicilin (MCIDAS), a protein that is necessary and sufficient to specify multiciliated cells in vertebrates. Here, we performed RNAseq on Xenopus laevis ectoderm in the presence of multicilin alone or multicilin and a domina...
ORGANISM(S): Xenopus laevis 
2014-07-10 | E-GEOD-59309 | biostudies-arrayexpress
ProteomicsSub-centrosomal mapping identifies augmin-TuRC as part of a centriole-stabilizing scaffold
Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis and MTOC function both require the microtubule nucleator -tubulin ring complex (TuRC). It is widely accepted that TuRC n...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027352 | Pride
Augmin Ciliogenesis Microtubules Centriole turc 
ProteomicsCEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion
The centriole-to-centrosome conversion is a mechanism of the centrosome maturation process that depends on the formation of a proper centriole wall structure. Beside the centriole wall biogenesis factors TUBD1 and TUBE1, CEP44 is involved in this process. Lack of CEP44 generates defects in the centr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD017332 | Pride
Human Centriol-to-centrosome conversion Poc1b Centrosome Cep44 
GenomicsThe Unkempt RNA binding protein reveals a local translation program in centriole overduplication
The Unkempt RNA binding protein reveals a local translation program in centriole overduplication
PRJNA1262847 | ENA
GenomicsThe SON splicing factor is required for intracellular trafficking that promotes centriole assembly
The SON splicing factor is required for intracellular trafficking that promotes centriole assembly
PRJNA689788 | ENA
ProteomicsMcIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle to maintain a proper number of centrioles in cells. Aberrations in centriole biogenesis can lead to cancer, developmental disorders and ciliopathies, yet the molecular determinants of centriole numbe...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD037043 | Pride
Mcidas Proteomics Phosphorylation Cell cycle Centrosome Plk4 
TranscriptomicsMiR-34b regulates multiciliogenesis during organ formation in zebrafish
Multiciliated cells possess multiple motile cilia on the cell surface and are widely distributed throughout the vertebrate body to perform important physiological functions by regulating fluid movement in the intercellular space. However the molecular mechanisms underlying multiciliogenesis are not ...
ORGANISM(S): Danio rerio 
2013-06-14 | E-MEXP-3893 | biostudies-arrayexpress
TranscriptomicsThe Unkempt RNA binding protein reveals a local translation program in centriole overduplication
Excess centrosomes cause defects in mitosis, cell-signaling, and cell migration, and therefore their assembly is tightly regulated. The divergent Polo kinase, PLK4, controls centriole duplication at the heart of centrosome assembly, and elevated PLK4 levels promote centrosome amplification (CA), a f...
ORGANISM(S): Homo sapiens 
2025-05-17 | GSE297133 | GEO
TranscriptomicsThe SON splicing factor is required for intracellular trafficking that promotes centriole assembly
Control of the number of centrosomes is critical for cell division, trafficking and cilia. Regulation of centrosome number occurs through the precise duplication of centrioles that reside in the center of centrosomes. Here we explored transcriptional control of centriole assembly by focusing on alte...
ORGANISM(S): Homo sapiens 
2021-12-22 | GSE164278 | GEO
ProteomicsCentriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1. Pcm1-/- mice display partially expressive perinatal lethality with survivors exhibiting hydrocephalus, oligospermia...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031920 | Pride
Mtecs Cilia 
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