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ProteomicsCAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors
γ-tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins, such as CAMSAPs, but the biochemical cross-talk between minus-end regulation pathways is poorly understood. Here, we reconstituted ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-30 | PXD048637 | Pride
Protein complex Camsaps Nucleation Trafficking Microtubule Tubulin 
ProteomicsSub-centrosomal mapping identifies augmin-TuRC as part of a centriole-stabilizing scaffold
Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis and MTOC function both require the microtubule nucleator -tubulin ring complex (TuRC). It is widely accepted that TuRC n...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027352 | Pride
Augmin Ciliogenesis Microtubules Centriole turc 
UnknownModular assembly of the principal microtubule nucleator γ-TuRC.
Not available
S-EPMC8789826 | biostudies-literature
Unknownγ-TuRC Heterogeneity Revealed by Analysis of Mozart1.
Not available
S-EPMC6065531 | biostudies-literature
UnknownCAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC.
Not available
S-EPMC10940162 | biostudies-literature
UnknownBiochemical reconstitutions reveal principles of human γ-TuRC assembly and function.
Not available
S-EPMC7844428 | biostudies-literature
UnknownThe Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores.
Not available
S-EPMC2859955 | biostudies-literature
UnknownMicrotubule Organizing Centers Contain Testis-Specific γ-TuRC Proteins in Spermatids of Drosophila.
Not available
S-EPMC8511327 | biostudies-literature
UnknownStructural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC.
Not available
S-EPMC11903878 | biostudies-literature
UnknownMolecular insight into how γ-TuRC makes microtubules.
Not available
S-EPMC8325954 | biostudies-literature
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