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ProteomicsIdentification of CDC20/CDC20B partners in HEK cells demonstrates that CDC20, but not CDC20B, interacts with multiple APC/C components
Multiciliated cells (MCCs) harbour dozens to hundreds of motile cilia, which beat in a synchronized and directional manner, thus generating hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation critically depends on the synthesis and release of numerous centrioles b...
ORGANISM(S): Homo sapiens (Human) 
2019-04-03 | PXD010629 | Pride
Motile cilia Deuterosome Centriole Plk1 Cdc20b Separase Cdc20 Cell cycle Hek cells 
TranscriptomicsAtorvastatin effect on SaOS2 osteosarcoma cells
SaOS2 osteosarcoma cells were cultured with or without atorvastatin (10 µM) for 6, 15 or 24h (2 biological replcates). RNA were isolated and hybridized to RNG microarrays. Background Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-24401 | biostudies-arrayexpress
TranscriptomicsMiRNA and lung cancer (INCA Project) - 16 RNG25k microarrays
To identify putative novel specific targets of mir-210, we overexpressed miR-210 as well as miR-34a and a siRNA targeted against E2F3 in A549 human adenocarcinoma cells by transfecting them with synthetic pre-miRNAs or a synthetic “negative” pre-miRNA as control (miR-Neg). RNA samples were harveste...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18695 | biostudies-arrayexpress
TranscriptomicsCharacterization of retinoic acid-regulated microRNAs
The aim of this study is to identify microRNAs (miRNAs) transcriptionnally regulated by retinoic acid (RA). For that purpose we have used the RA-based treatment of the Acute Promyelocytic Leukemia (APL) as a model. This malignancy is characterised by a differentiation arrest of granulopoiesis at the...
ORGANISM(S): Homo sapiens 
2008-11-17 | E-GEOD-11379 | biostudies-arrayexpress
TranscriptomicsMiRNA and lung cancer (INCA project) - 40 miRNAs microarrays
MicroRNA expression pattern in 20 pairs of primary lung cancers and their corresponding non cancerous lung tissues. These specimens were obtained from the Nice Hospital Tumor Bio Bank, France. Dye swap-experiment comparing cancerous tissue versus adjacent normal lung tissue.
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18692 | biostudies-arrayexpress
TranscriptomicsMiRNA and lung cancer (INCA project) - 26 RNG25k microarrays
Gene expression analysis in 13 pairs of primary lung cancers and their corresponding non cancerous lung tissues. These specimens were obtained from the Nice Hospital Tumor Bio Bank, France. Dye swap-experiment comparing cancerous tissue versus adjacent normal lung tissue.
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18694 | biostudies-arrayexpress
TranscriptomicsMicroRNA signature of thyroid tumors of uncertain malignancy
Well-differentiated tumours (WDT) of the thyroid gland can be difficult to diagnose. Focal nuclear clearing can be suggestive of a papillary thyroid carcinoma (PTC), while questionable vascular or capsular penetration may raise the possibility of diagnosis of a follicular thyroid carcinoma (FTC). Th...
ORGANISM(S): Homo sapiens 
2011-08-21 | E-GEOD-15740 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis during the time course of regeneration of the human airway mucociliary epithelium
The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). We used microarrays to detail the global programme of gene expression that occurs during regeneration and ciliogenes...
ORGANISM(S): Homo sapiens 
2011-06-06 | E-GEOD-22142 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of differentiated HNECs stimulated by IL4, IL13, IFNalpha, IFNbeta, IFNgamma and controls
Background: In asthma, airway epithelium remodeling can already be detected during childhood, and epithelial cells are more susceptible to virus and oxidative stress. Their exact role in natural history and severity of children allergic respiratory disease remains however surprisingly unexplored. A...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19182 | biostudies-arrayexpress
TranscriptomicsNasal epithelium gene expression profiling in child respiratory allergic disease
Background: In asthma, airway epithelium remodeling can already be detected during childhood, and epithelial cells are more susceptible to virus and oxidative stress. Their exact role in natural history and severity of children allergic respiratory disease remains however surprisingly unexplored. A...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19187 | biostudies-arrayexpress
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