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ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - label-free MS RAPIDASH of E12.5 mouse forebrain
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD054303 | Pride
Acquity uplc m-class system Embryo Orbitrap elite Forebrain Ribosome Ribosome-associated proteins Mouse 
ProteomicsGene- and species-specific Hox mRNA translation by ribosome expansion segments
Ribosomes have been suggested to directly control gene regulation, however regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. ESs are remarkably variable ...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-19 | PXD021678 | Pride
C3h/10t1/2 6plex tmt Hoxa9 4xs1m aptamer Rna structure Lc msms Internal initiation Internal ribosome entry site Affinity purification Mouse fvb embryo e11.5 Ribosome Hox cluster Mrna translation Stem-loop Rna-protein interaction Ribosomal rna 
ProteomicsA proteomic roadmap of ribosome heterogeneity during human embryonic stem cell differentiation
Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types to control cell fate remains unknown. To determine the magnitude of ribosome heterogeneity and its functional contribution to cell fate specification, we measu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD032904 | Pride
Differentiation Ribosome Tandem mass tags (tmt) Human embryonic stem cell 
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - TMT MS RAPIDASH comparison with original chromatographic purification of yeast ribosomes (Meskauskas, et al. 2011)
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-12 | PXD054427 | Pride
Acquity uplc m-class system Orbitrap elite Chromatography Ribosome Tmt ms Ribosome-associated proteins Mouse 
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - TMT MS RAPIDASH comparison with sucrose cushion of E14 mESCs
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-12 | PXD054298 | Pride
Acquity uplc m-class system Orbitrap elite Sucrose cushion Ribosome Tmt ms Ribosome-associated proteins Mouse 
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - label-free MS RAPIDASH of L36-FLAG and S17-FLAG E14 mESCs
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-12 | PXD054300 | Pride
Acquity uplc m-class system Embryonic stem cell Orbitrap elite Ribo-flag immunoprecipitation Ribosome Ribosome-associated proteins Mouse 
ProteomicsRAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues, cancer cells, and macrophages - TMT MS RAPIDASH of E12.5 mouse limbs, forebrain, and liver
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of technologies to enrich RAPs across sample types has prevented systematic analysis of RAP identities, dynamics, and functions. W...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-12 | PXD054304 | Pride
Acquity uplc m-class system Embryo Orbitrap elite Forebrain Liver Ribosome Tmt ms Ribosome-associated proteins Mouse Limbs 
ProteomicsA subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. Here, we present ribosome expansion microscopy (RiboExM) to visualize individual ribosomes and an optogenetic proximity-labeling technique (ALIBi) to p...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-05 | PXD058668 | Pride
Ribosome-associated protein Ribosome Ribosome biogenesis Subcellular localization Mrna translation 
UnknownA versatile toolbox for determining IRES activity in cells and embryonic tissues
Not available
S-SCDT-10_1038-S44318-025-00404-5 | biostudies-other
TranscriptomicsTranscription profiling of mouse spermatogonia in wild type vs Zpf145 knockout backgrounds reveals Plzf is essential for maintenance of spermatogonial stem cells.
Expression analysis of spermatogonia in a wild type or Zfp145 knock out background
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1399 | biostudies-arrayexpress
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