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TranscriptomicsExpression data from human cord blood CD161++/CD161+/CD161- CD8+ T cell subsets
We used microarray to compare gene expression between CD161++/CD161+/CD161-CD8+ T cells from human cord blood. Lymphocytes from freshly obtained human cord blood samples were isolated by Ficoll density centrifugation. CD8+ T cells were purified by negative selection using magnetic beads and subseque...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33424 | biostudies-arrayexpress
TranscriptomicsExpression data from healthy human CD161++CD8aa and CD161++CD8ab T cells
We used microarrays to compare gene expression between healthy human CD161++CD8aa and CD161++CD8ab T cells. We sorted freshly obtained peripheral blood mononucleocytes from healthy controls by first using magnetic beads to negatively select for CD8a+ T cells, fluorescently labelling isolated cells w...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33374 | biostudies-arrayexpress
TranscriptomicsRNA-seq of a controlled porcine model of trauma and haemorrhagic shock treated by fluid resuscitation against untreated controls
This was a randomised study in terminally anaesthetised female cross-bred Large White pigs. Initially, animals were anaesthetised and instrumented for continuous physiological monitoring and sampling; blood samples were collected upon initiation of the surgery (line-in, T = -150 minutes). Following ...
ORGANISM(S): Sus scrofa 
2026-10-28 | E-MTAB-16011 | biostudies-arrayexpress
MetabolomicsToxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be investigated by using different in vitro models and dedicated metabolomics techniques to enhance the number of relevant findings. The presen...
2023-10-10 | MTBLS1481 | MetaboLights
TranscriptomicsHuman MAIT and CD8++ cell development
This SuperSeries is composed of the following subset Series: GSE33374: Expression data from healthy human CD161++CD8aa and CD161++CD8ab T cells GSE33424: Expression data from human cord blood CD161++/CD161+/CD161- CD8+ T cell subsets Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33425 | biostudies-arrayexpress
TranscriptomicsGene expression changes during retinal development and rod specification.
Photoreceptor disorders are collectively known as retinal degeneration (RD), and include retinitis pigmentosa (RP), cone-rod dystrophy and age related macular degeneration (AMD). These disorders are largely genetic in origin; individual mutations in any one of >200 genes cause RD, making mutation sp...
ORGANISM(S): Mus musculus 
2015-01-20 | E-GEOD-59201 | biostudies-arrayexpress
TranscriptomicsImmune cells direct epithelial maturation during early human lung development
The adult human lung harbours a significant proportion of immune cells, which are known to play a crucial role in both normal lung homeostasis and pathogenesis. In this work, we collected CD45-enriched human lung cells from 6 to 22 week post conception (pcw) and built a single-cell transcriptome and...
ORGANISM(S): Homo sapiens 
2022-12-09 | E-MTAB-11528 | biostudies-arrayexpress
TranscriptomicsIdentification of cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and is associated with worse prognosis in heart failure patients. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the rel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-13016 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human trauma patients with and without haemorrhagic shock
Patients were recruited between February 2008 and March 2019 through the Activation of Coagulation and Inflammation in Trauma (ACIT-II) study, a prospective platform cohort study evaluating aspects of coagulation and inflammation in trauma patients (NHS REC: 07/Q0603/20). Patients at the Royal Londo...
ORGANISM(S): Homo sapiens 
2026-10-29 | E-MTAB-16212 | biostudies-arrayexpress
TranscriptomicsRNA-Seq study of skin and blood samples from prospectively-recruited, deeply-phenotyped discovery and refinement psoriasis cohorts, during targeted treatment with adalimumab or ustekinumab
The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) consortium, prospectively recruited deeply-phenotyped discovery and refinement psoriasis patient cohorts, during the early phase of treatment with two distinct biologics, adalimumab (TNF inhibitor) and ustekinumab (IL-12/23 inhibitor)...
ORGANISM(S): Homo sapiens 
2025-11-19 | E-MTAB-14509 | biostudies-arrayexpress
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