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TranscriptomicsTranscription profiling of C. elegans small RNA cloning and array methods for reproducibility and quantitation
This experiment was for the purpose of testing our small RNA cloning and array methods for reproducibility and quantitation (see Axtell and Bartel). This experiment consists of four hybridizations of C. elegans small RNA. Hybridizations test a Cy3-labeled biological sample against a constant, synthe...
ORGANISM(S): synthetic DNA 
2005-05-01 | E-MEXP-291 | biostudies-arrayexpress
TranscriptomicsFormation, regulation and evolution of 3' UTRs in Caenorhabditis elegans
Much of posttranscriptional mRNA regulation occurs through cis-acting sequences in mRNA 3´ untranslated regions (UTRs), which interact with specific proteins and ribonucleoprotein complexes that modulate translation, mRNA stability and subcellular localization. Studies in Caenorhabditis elegans hav...
ORGANISM(S): Caenorhabditis elegans 
2010-12-24 | E-GEOD-24924 | biostudies-arrayexpress
TranscriptomicsDevelopmental timecourse of C. elegans small RNAs with 5p monophosphates
These datasets profile the expression of small RNAs with 5p monophosphates and 3p hydroxyls (including miRNAs, 21U-RNAs) across C. elegans development and in dauer, glp-4 mutant, and mixed-stage wt worms. These datasets were prepared in the David P. Bartel laboratory using T4 RNA ligase Rnl2(1-249)....
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-11734 | biostudies-arrayexpress
ProteomicsControl of protein accumulation by the LON2 peroxisomal protease and autophagy
Peroxisomes are membrane-bound eukaryotic organelles that house essential metabolic pathways. Many of these pathways generate damaging reactive oxygen species (ROS) that also function as signaling molecules. In Arabidopsis thaliana, damaged or obsolete peroxisomal proteins can be degraded by the LON...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-06 | PXD022921 | Pride
Protease Peroxisomes Pexophagy Chaperone 
GenomicsDevelopmental timecourse of C. elegans small RNAs with 5p monophosphates
These datasets profile the expression of small RNAs with 5p monophosphates and 3p hydroxyls (including miRNAs, 21U-RNAs) across C. elegans development and in dauer, glp-4 mutant, and mixed-stage wt worms. These datasets were prepared in the David P. Bartel laboratory using T4 RNA ligase Rnl2(1-249)....
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | GSE11734 | GEO
TranscriptomicsMaternal and paternal genomes contribute equally to the transcriptome of early plant embryos
In animals, maternal gene products deposited into eggs regulate embryonic development before activation of the zygotic genome. In plants, an analogous period of prolonged maternal control over embryogenesis is thought to occur based on gene-expression studies. However, other gene-expression studies ...
ORGANISM(S): Arabidopsis thaliana 
2012-01-12 | E-GEOD-33713 | biostudies-arrayexpress
ProteomicsProteomic Adaptation of Clostridioides difficile to Treatment with the Antimicrobial Peptide Nisin
Clostridioides difficile is the leading cause of antibiotics-associated diarrhea but can also result in more serious, life-threatening conditions. As incidence of C. difficile infections in hospitals is increasing, both in frequency and severity, and antibiotic-resistant C. difficile strains are adv...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-02-18 | PXD021684 | Pride
Nisin C. difficile Proteomics Mass spectrometry Antimicrobial peptides Antibiotic resistance 
TranscriptomicsMutant analysis of C. elegans small RNAs with 5p monophosphates
These datasets profile the expression of small RNAs with 5p monophosphates and 3p hydroxyls (including miRNAs, 21U-RNAs) in young adult worms from the wt, prg-1 mutant, and fog-2 mutant backgrounds. These datasets were prepared in the Craig C. Mello laboratory using T4 RNA ligase 1. Keywords: miRNA...
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-11735 | biostudies-arrayexpress
TranscriptomicsMutant analysis of C. elegans small RNAs, 5p-end-independent
These datasets profile the expression of small RNAs with 3p hydroxyls (including endo-siRNAs, miRNAs, and 21U-RNAs) in young adult worms from the wt and prg-1 mutant backgrounds. They were prepared using an approach that captures small RNAs independent of the covalent status of their 5p termini, as...
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-11736 | biostudies-arrayexpress
GenomicsAmplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...
ORGANISM(S): Caenorhabditis elegans 
2012-01-06 | E-GEOD-32631 | biostudies-arrayexpress
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