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ProteomicsA quick guideline for PRM method development applied to target proteomics in biological fluids
Combining in-silico analysis, serum high abundant protein depletion, and DDA and PRM acquisitions, we established a simple workflow to select PRM high response peptides for protein quantification in serum. The workflow enables evaluating peptide intensity, MS2 match with the spectral library, peptid...
ORGANISM(S): Homo sapiens (Human) 
2024-02-05 | PXD045089 | Pride
Complement system Prm Human serum Quantitative proteomics Lc-ms/ms 
ProteomicsProteomic Analysis of Canine Extracellular Matrix in Mammary Tumor Progression
Canine mammary gland tumors are common and bear striking similarities to human breast cancer, making them a valuable model for comparative oncology. This study examined changes in the extracellular matrix (ECM) associated with tumor progression in spontaneous canine mammary carcinomas, aiming to ide...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2026-04-13 | PXD074203 | Pride
Proteomics Canine mammary tumor Extracellular matrix Lc-ms/ms 
ProteomicsAffinity Purification of ISWI chromatin remodeler in Trypanosoma cruzi
Chromatin remodeling is a general mechanism involved in DNA-dependent processes, including gene expression regulation. ISWI ATPase is the catalytic subunit in diverse chromatin remodeling complexes that changing histone–DNA interactions and therefore play a pivotal role in different nuclear processe...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2020-05-22 | PXD017869 | Pride
Affinity purification Iswi Trypanosoma cruzi Lc-ms/ms 
ProteomicsProteomics and peptidomics of breast cancer subtypes
In our study, we applied high-throughput mass spectrometry, bioinformatic, and machine learning approaches to investigate the proteome, including noncoding RNA (ncRNA)–derived micropeptides, of different breast cancer subtypes. In total, 19 tumor and 18 paired nontumor samples were used to obtain th...
ORGANISM(S): Homo sapiens (Human) 
2024-11-12 | PXD057759 | Pride
Human Breast cancer Peptidomics Proteomics Lc-ms/ms 
ProteomicsHigh-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
The project contains raw and result files from a comparative proteomic analysis of malignant [primary breast tumor (PT) and axillary metastatic lymph nodes (LN)] and non-tumor [contralateral (NCT) and adjacent breast (ANT)] tissues of patients diagnosed with invasive ductal carcinoma. A label-free m...
ORGANISM(S): Homo sapiens (Human) 
2019-07-15 | PXD012431 | Pride
Proteomics Contralateral breast tissue Label-free mass spectrometry Breast cancer Bioinformatics analysis 
ProteomicsT. brucei MAPKLK1 knockdown - The MAP kinase MAPKLK1 is essential to Trypanosoma brucei proliferation and regulates proteins involved in mRNA metabolism
Pathogenic trypanosomatids have a large number of protein kinases and phosphatases in comparison to other organisms. Moreover, post-translational modifications have key role in the gene expression control in these cells, reinforcing the relevance of the phosphorylation process. Nevertheless little i...
ORGANISM(S): Trypanosoma brucei 
2017-10-17 | PXD006048 | Pride
Map kinase Ltq orbitrap xl etd Trypanosoma brucei 
ProteomicsDifferentially Expressed Proteins in Plasma-Derived Extracellular Vesicles from Chronic Myeloid Leukemia Patients
Chronic myeloid leukemia (CML) is driven by the BCR::ABL1 fusion gene. Although tyrosine kinase inhibitors (TKIs) have transformed outcomes, treatment resistance persists. Plasma extracellular vesicles (EVs) reflect their cell of origin and may serve as stable biomarkers. To characterize the plasma ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD071200 | Pride
T315i Extracellular vesicles Chronic myeloid leukemia Proteomics Biomarkers 
ProteomicsScreening of exosome-derived proteins and their potential as biomarkers to diagnostic and prognostic for pancreatic cancer
This study aimed to investigate the proteomic landscape of plasma exosomes from patients diagnosed with PDAC and IPMN, compared to healthy controls (CT), in order to identify potential biomarkers with prognostic and diagnostic values. Additionally, the study aimed to understand the functional role o...
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD042543 | Pride
Mass spectrometry Pancreatic cancer Exosome Proteomics Biomarkers 
ProteomicsIntegrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer
The project contains raw and result files from a proteomic profiling of a male breast cancer (MBC) case. Label-free quantification-mass spectrometry (LFQ-MS) and bioinformatics analysis were employed to investigate the differentially expressed proteins (DEPs) among distinct tissue samples: the prima...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012453 | Pride
Proteomics Signaling pathways Label-free mass spectrometry Bioinformatics analysis Male breast cancer 
ProteomicsTrypanosomatid extracellular vesicles as potential immunogens in Chagas disease
Extracellular vesicles (EVs) from parasite protozoa can induce efficient immunity, which makes them useful for probable next-generation vaccines, more specifically against Trypanosoma cruzi infection. Howevver, the mechanisms involved in the protective responses have not been fully elucidated. To in...
ORGANISM(S): Trypanosoma rangeli Trypanosoma cruzi Dm28c Phytomonas serpens 
2025-01-21 | PXD040019 | Pride
Immunogens Trypanosomatid Extracellular vesicles Chagas disease 
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