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MetabolomicsGut Microbiota Dysbiosis is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis

The co-occurrence of gut microbiota dysbiosis and bile acids (BAs) metabolism alteration has been reported in several human liver diseases. However, the gut microbiota dysbiosis in infantile cholestatic jaundice (CJ), and the linkage between gut bacterial changes and alterations of BAs metabolism...

2019-11-30 | MTBLS1295 | MetaboLights
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
UnknownDisease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms.
Not available
S-EPMC12380619 | biostudies-literature
ProteomicsDifferential UBE2H-CTLH E2-E3 ubiquitylation modulesregulate erythroid maturation
The developmentof haematopoietic stem cellsinto mature erythrocytes–erythropoiesis –is a controlled process characterized by cellular reorganisation and drastic reshaping of the proteome landscape.Failure of ordered erythropoiesis isassociated with anaemias and haematological maligna...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031992 | Pride
Ube2h Proteomics Dia Ms Gid complex Ubiquitination E2 Ctlh complex E3 
ProteomicsOxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration(AMD), the leading cause of blindness in the elderly, with retinal pigment epithelial (RPE) cells playing a key role. To better understand the cytotoxic mechanisms underlying oxidative stress, we used cell cu...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-19 | PXD043613 | Pride
Oxidative stress Lysosome Age-related macular degeneration Aging Retina 
UnknownOxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
Not available
S-EPMC10399446 | biostudies-literature
UnknownThe Rapid Evaluation of COVID-19 Vaccination in Emergency Departments for Underserved Patients Study.
Not available
S-EPMC8165082 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
UnknownIGLV3-21R110 mutation has prognostic value in patients with treatment-naive chronic lymphocytic leukemia.
Not available
S-EPMC10726246 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
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