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ProteomicsDecrypting drug actions and protein modifications by dose- and time-resolved chemical proteomics
Measuring dose-dependent effects of drugs on post-translational modifications on a proteome-wide scale reveals how these drugs work in cells. Here, we present a quantitative chemical proteomic approach termed decryptM, able to assess target and pathway engagement as well as the mode of action (MoA)...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD037285 | Pride
Kat Screen Drug mode of action Post-translational modifciation Time-resolved Inhibitors Decryptm Proteome-wide Hdac Dose-resolved Kinase 
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics-2
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-29 | MSV000093533 | MassIVE
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091043 | MassIVE
ProteomicsUnified workflow for the rapid and in-depth characterization of bacterial proteomes
Among the kingdoms of life, bacteria are by far the most abundant, but also the most diverse organisms. Due to this excessive diversity, finding a unified, comprehensive and safe workflow for quantitative bacterial proteomics is highly challenging. In this study, we have systematically evaluated and...
ORGANISM(S): Bacillus Subtilis (ncbitaxon:1423) Enterococcus Faecalis (ncbitaxon:1351) Vibrio Proteolyticus (ncbitaxon:671) Lactobacillus Delbrueckii (ncbitaxon:1584) Burkholderia Cepacia (ncbitaxon:292) Streptococcus Mitis (ncbitaxon:28037) Staphylococcus Aureus (ncbitaxon:1280) Escherichia Coli (ncbitaxon:562) Bifidobacterium Bifidum (ncbitaxon:1681) Sphingobacterium Spiritivorum (ncbitaxon:258) Deinococcus Radiodurans (ncbitaxon:1299) Prevotella Melaninogenica (ncbitaxon:28132) Micrococcus Luteus (ncbitaxon:1270) Cutibacterium Acnes (ncbitaxon:1747) Brevundimonas Diminuta (ncbitaxon:293) Pseudomonas Aeruginosa (ncbitaxon:287) Anoxybacillus Flavithermus (ncbitaxon:33934) Acetobacter Aceti (ncbitaxon:435) Mycolicibacterium Smegmatis (ncbitaxon:1772) Listeria Monocytogenes (ncbitaxon:1639) Clostridium Sporogenes (ncbitaxon:1509) Bacillus Cereus (ncbitaxon:1396) Corynebacterium Glutamicum (ncbitaxon:1718) 
2023-01-18 | MSV000091088 | MassIVE
ProteomicsData, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing
As the SARS-CoV-2 pandemic continues to spread, thousands of scientists around the globe have changed research direction to understand better how the virus works and to find out how it may be tackled. To facilitate proteomic research on SARS-CoV-2, we presents deep-scale proteomes of common cell lin...
ORGANISM(S): Chlorocebus Sabaeus (ncbitaxon:60711) Chlorocebus Aethiops (ncbitaxon:9534) Homo Sapiens (ncbitaxon:9606) 
2020-07-17 | MSV000085774 | MassIVE
ProteomicsProteomic diversity in bacteria: Insights and implications for bacterial identification
We acquired the largest bacterial proteomic resource, covering 303 species, 119 genera, and five phyla. The proteome coverage is, on average, over 50%. Additionally, we acquired further datasets for bacterial identification algorithm validation: i) 303 species at a 30-minute gradient (38 samples per...
ORGANISM(S): Bacteria (ncbitaxon:2) 
2024-12-06 | MSV000096603 | MassIVE
ProteomicsData, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing
As the SARS-CoV-2 pandemic continues to spread, thousands of scientists around the globe have changed research direction to better understand how the virus works and to find out how it may be tackled. The number of manuscripts on pre-print servers is soaring and peer-reviewed publications using mass...
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
2020-09-11 | PXD019680 | panorama
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
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