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ProteomicsDecrypting drug actions and protein modifications by dose- and time-resolved chemical proteomics
Measuring dose-dependent effects of drugs on post-translational modifications on a proteome-wide scale reveals how these drugs work in cells. Here, we present a quantitative chemical proteomic approach termed decryptM, able to assess target and pathway engagement as well as the mode of action (MoA)...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD037285 | Pride
Kat Screen Drug mode of action Post-translational modifciation Time-resolved Inhibitors Decryptm Proteome-wide Hdac Dose-resolved Kinase 
UnknownThe kinetic dose limit in room-temperature time-resolved macromolecular crystallography.
Not available
S-EPMC3284346 | biostudies-literature
UnknownDose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins.
Not available
S-EPMC6608622 | biostudies-literature
ProteomicsTime- and dose-resolved proteome of PM2.5 exposure in rat model
this paper used Mass spectrometry, Fast-seq, and catTFRE to study the pattern of 6316 proteins as well as 387 Transcription factors associated with PM2.5 in both short-term and long-term rat injury models.
ORGANISM(S): Rattus Norvegicus 
2020-05-27 | PXD019404 |
UnknownA time-resolved experimental-mathematical model for predicting the response of glioma cells to single-dose radiation therapy.
Not available
S-EPMC8271006 | biostudies-literature
UnknownDiagnostic accuracy and efficiency of combined acquisition of low-dose time-resolved and single-phase high-resolution contrast-enhanced magnetic resonance angiography in a single session for pre-angiographic evaluation of spinal vascular disease.
Not available
S-EPMC6438605 | biostudies-literature
ModelsBachmann2011_JAK2-STAT5_FeedbackControl
This model is from the article: Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U. ...
2024-09-02 | BIOMD0000000347 | BioModels
UnknownSpatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona.
Not available
S-EPMC5008221 | biostudies-literature
TranscriptomicsTranscription profiling of mouse liver genomic responses to ciguatoxin (P-CTX-1)
Ciguatoxins (CTX) are polyether neurotoxins responsible for ciguatera, the most common fish-borne food poisoning in humans. This study characterizes the global transcriptional response of mouse liver to a symptomatic dose (0.26 ng/g) of the highly potent Pacific ciguatoxin-1 (P-CTX-1). At 1 h post...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10768 | biostudies-arrayexpress
UnknownDecrypting drug actions and protein modifications by dose- and time-resolved proteomics.
Not available
S-EPMC7615311 | biostudies-literature
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