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TranscriptomicsTranscription profiling of human adenocarcinoma cell line A549 over-expressing ELMOD2
ELMOD2 cDNA from the IMAGE clone 3897166 was cloned into the pDsRed-Monomer-N1 expression vector. ELMOD2 was overexpressed in the A549(adenomcarcinoma)cell line and cells transfected with empty vector were considered controls. Transcript profiles were compared with the Affymetrix Hgu133plus2 arrays....
ORGANISM(S): Homo sapiens 
2009-12-07 | E-MEXP-1838 | biostudies-arrayexpress
TranscriptomicsDevelopment of a microarray for Enchytraeus albidus (Oligochaeta): Preliminary tool with diverse applications
Standard bioassays allow hazard assessment at the population level, but much remains to be learned about the molecular level response of organisms to stressors. The main aim of this study was the development of a DNA microarray for Enchytraeus albidus, a common soil worm species. Further, this micro...
ORGANISM(S): Enchytraeus albidus 
2011-03-30 | E-GEOD-18569 | biostudies-arrayexpress
TranscriptomicsEffect of Cu-Nanoparticles versus Cu-salt in Enchytraeus albidus (Oligochaeta): differential gene expression through microarray analysis
Despite the increased utilization of nanoparticles, the behavior and effect in the environment is largely unknown and few resources are available for health and environmental effect studies. Enchytraeids are extensively used in studies of soil ecotoxicology and recently, a cDNA microarray for Enchyt...
ORGANISM(S): Enchytraeus albidus 
2011-09-07 | E-GEOD-26331 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis in Enchytraeus albidus exposed to natural and chemical stressors at different exposure periods
The soil oligochaete Enchytraeus albidus is a standard test organism used in biological testing for Environmental Risk Assessment (ERA). Although effects are known at acute and chronic level, through survival, reproduction and avoidance behaviour endpoints, very little is known at the sub-cellular a...
ORGANISM(S): Enchytraeus albidus 
2011-08-31 | E-GEOD-26896 | biostudies-arrayexpress
TranscriptomicsCRISPR screen exploring resistance to AKTi (Capivasertib) in ER+ Breast Cancer in MCF7, T47D and CAMA-1 cell lines
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
2026-05-25 | E-MTAB-16438 | biostudies-arrayexpress
TranscriptomicsDeregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients
Presence of BM-infiltrating neuroblastoma (NB) cells occurs in about 50% of patients affected by this peculiar pediatric cancer. Children aged more than 18 months at diagnosis with metastatic NB are high-risk patients with 25-30% overall survival at 5 years, despite multimodal aggressive therapy. Li...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-65153 | biostudies-arrayexpress
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
ProteomicsVagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in a Multiple Sclerosis rodent model.
This study investigated the effect of Vagus Nerve Stimulation (VNS) on innate neuroinflammation and remyelination in lysolecithin (LPC) induced demyelination, a preclinical model for Multiple Sclerosis (MS). In a first experiment (demyelination experiment), LPC was injected in the corpus callosum of...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-10 | PXD050858 | Pride
Vagus nerve stimulation (vns) Neuroinflammation Remyelination Synapses Multiple sclerosis (ms) Lc-ms/ms 
TranscriptomicsTonsil Atlas FASTQ files
This repository contains all the FASTQ files for the five data modalities (scRNA-seq, scATAC-seq, Multiome, CITE-seq+scVDJ-seq, and spatial transcriptomics) used in the article \\"An Atlas of Cells in The Human Tonsil,\\" published in Immunity in 2024. Inspired by the TCGA barcodes, we have named ea...
ORGANISM(S): Homo sapiens 
2024-05-02 | E-MTAB-13687 | biostudies-arrayexpress
TranscriptomicsExpression profile of Maize (Zea mays L.) Embryonic Axes During Germination: Regulation of Ribosomal Protein mRNAs.
Seed germination is a critical developmental process in plant propagation. Knowledge of the gene expression patterns in this critical process is important in order to understand the main biochemical reactions involved in successful germination, specially for economically relevant plants such as M...
ORGANISM(S): Zea mays 
2011-07-31 | E-GEOD-27648 | biostudies-arrayexpress
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