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TranscriptomicsDrug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural degeneration and subsequent disability requires remyelination through the generation of new oligodendrocytes, but current treatments exclusively ta...
ORGANISM(S): Mus musculus 
2015-04-13 | E-GEOD-63804 | biostudies-arrayexpress
TranscriptomicsDysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19403 | biostudies-arrayexpress
TranscriptomicsRetinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination
The efficiency of central nervous system (CNS) remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study we show that expression of genes i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
TranscriptomicsInhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
We used transcription-profiling to identify mitogen-activated protein kinase (Mapk) signaling as an important regulator involved in the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes. We show in tissue culture that activation of Mapk signaling by elevation of intrac...
ORGANISM(S): Rattus norvegicus 
2013-08-29 | E-GEOD-50042 | biostudies-arrayexpress
ProteomicsFingolimod and remyelination - Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model
Remyelinating substances could be an essential supplement to immunomodulatory medications, optimizing the treatment of multiple sclerosis (MS) patients. Fingolimod is a sphingosine-1-phosphate receptor (S1PR) modulator and crosses the blood-brain barrier. Central nervous system (CNS) cells express S...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-20 | PXD012676 | Pride
Brain Cpz Tissue Proteomics Tmt Mass spectrometry Qe-hf Fingolimod Mouse Multiplexing 
GenomicsAge-impaired remyelination is associated with dysregulated microglial transitions.
Age-impaired remyelination is associated with dysregulated microglial transitions.
PRJNA1186235 | ENA
GenomicsSingle-cell profiling of remyelination in the LPC model
Single-cell profiling of remyelination in the LPC model
PRJNA1157862 | ENA
ProteomicsVagus Nerve Stimulation enhances remyelination and decreases innate neuroinflammation in a Multiple Sclerosis rodent model.
This study investigated the effect of Vagus Nerve Stimulation (VNS) on innate neuroinflammation and remyelination in lysolecithin (LPC) induced demyelination, a preclinical model for Multiple Sclerosis (MS). In a first experiment (demyelination experiment), LPC was injected in the corpus callosum of...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-10 | PXD050858 | Pride
Vagus nerve stimulation (vns) Neuroinflammation Remyelination Synapses Multiple sclerosis (ms) Lc-ms/ms 
GenomicsAcute TREM2 Blockade Impairs Remyelination by Reducing MAFB-High Microglia
Acute TREM2 Blockade Impairs Remyelination by Reducing MAFB-High Microglia
PRJNA1208102 | ENA
GenomicsTRAP-seq of mouse astrocytes involved in central nervous system remyelination
TRAP-seq of mouse astrocytes involved in central nervous system remyelination
PRJEB39118 | ENA
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