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ProteomicsStructure of NDH the complex I-like molecule of oxygenic photosynthesis
Cyclic electron flow (CEF) around photosystem I (PSI) is a mechanism by which photosynthetic organisms balance levels of ATP and NADPH necessary for efficient photosynthesis1,2. The NAD(P)H dehydrogenase-like complex (NDH) is a key component of this pathway in most oxygenic photosynthetic organisms3...
ORGANISM(S): Thermosynechococcus elongatus BP-1 
2019-02-18 | PXD012206 | Pride
Cyclic electron flow Photosynthesis Nad(p)h dehydrogenase-like complex Bioenergetics Membrane protein structure Electron cryo-microscopy 
ProteomicsTom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress
Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early onset Parkinson disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial quality control by triggering mitophagy mediated by the ubiquitin ligase Parkin. Upon mitochondrial damage, PINK1 accumulates on th...
ORGANISM(S): Homo sapiens (Human) 
2024-03-02 | PXD047765 | Pride
Pink1 Human Tom complex Mitochondria Tim complex Parkinson's 
ProteomicsProteomics of rat neonatal cardiac fibroblasts
Gβγ subunits are involved in many different signalling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ, we investigated the functional role of Gβγ signalling in regulation of GPCR-mediated gene expression in primary rat neonatal...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD025993 | Pride
Gnb1 Rat cardiac fibroblasts Angiotensin ii Bottom-up proteomics 
ProteomicsAn Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry
Patient-derived organoids from induced pluripotent stem cells have emerged as a model for studying human diseases beyond conventional two-dimensional (2D) cell culture. As such, the development of robust methods to study global proteostasis and protein turnover in organoids will remain essential as ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD032169 | Pride
Midbrain organoid Midbrain Silac Half-life determination Turnover D3-leucine Topograph Organoid 
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