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TranscriptomicsTranscription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression modulates transcription responses in vivo
Background: We hypothesized that spleen microarray gene expression profiles analyzed with contemporary pathway analysis software would provide molecular pathways of interest and target genes that might help explain the affect of bcl-2 on improving survival during sepsis. Methods: Two mouse models of...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5811 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SCLC cell line set 2
RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...
ORGANISM(S): Homo sapiens 
2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress
ProteomicsComplementary Backbone and Side-chain Analysis of Drug – Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics
Characterizing and distinguishing protein-ligand interactions is crucial for understanding cellular metabolism and guiding drug discovery and development. We employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) and a new Fenton chemistry-based approach to protein oxidative mass spectrometry...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD050663 | Pride
Hdx Ox-ms Bcl2 Binding 
TranscriptomicsABT-737 treatment induces regulation and activation of pathways implicated in cell survival, proliferation and stem cells in treated AML mice survival, proliferation and stem cells in treated AML mice
Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow blast infiltration. Using a transgenic mouse model, MRP8[NRASD12/hBCL-2], in which the NRAS:BCL-2 complex at the mitochondria induces MDS progressing to AML with dysplastic featur...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-48601 | biostudies-arrayexpress
ProteomicsDevelopment and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molec...
ORGANISM(S): Homo sapiens (Human) 
2024-03-12 | PXD049976 | Pride
Protac Crystal structure Ubiquitin Ternary complex Degrader E3 ligase Bcl-xl/bcl-2 
ProteomicsDevelopment and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molec...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-21 | MSV000094144 | MassIVE
TranscriptomicsBCL-2 overexpression attenuates p53 stabilization and activation following RiBi inhibitors treatment
RNA-seq experiment performed in SUDHL-5 cells incubated with RiBi inhibitors (Doxorubicin, Actinomycin D, CX-5461) for 6h in the presence or absence of BCL-2.
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14977 | biostudies-arrayexpress
ProteomicsBCL-2 Regulation and Upstream Signal Transduction Modulate Venetoclax Resistance in Multiple Myeloma: New Avenues for Therapeutic Intervention
This study aimed to investigate the mechanisms underlying venetoclax (VTX) resistance in multiple myeloma (MM) and develop strategies to prevent or overcome resistance. VTX resistant human myeloma cell lines (HMCLs) were established and analyzed using whole exome sequencing (WES), mRNA-sequencing (m...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047149 | Pride
Venetoclax Acquired resistance Bcl-2 Proteomics Multiple myeloma 
TranscriptomicsBCL-2 pathway counteracts aneuploidy in mammalian embryos
DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise ...
ORGANISM(S): Mus musculus 
2020-03-26 | E-MTAB-8752 | biostudies-arrayexpress
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 3
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080268 | MassIVE
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