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Transcriptomicswenyan
Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy with unknown etiology. The disease mostly occurs in children between the ages of 3 and 13 in a diagonal belt-like area ranging from Northeast to Southwest China. We carried out this microarray analysis to investigate the differenc...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-MTAB-2494 | biostudies-arrayexpress
TranscriptomicsPeripheral blood mononuclear cells, control vs. Kashin-Beck Disease
Objective: To investigate the differences between the gene expression profiles in peripheral blood mononuclear cells (PBMC) from normal controls and patients with Kashin-Beck disease (KBD). Methods: Twenty KBD patients and 12 normal subjects were selected from a KBD-endemic area and divided into fo...
ORGANISM(S): Homo sapiens 
2011-09-22 | E-GEOD-32127 | biostudies-arrayexpress
MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
TranscriptomicsHuman Peripheral blood mononuclear cells (PBMCs): Control vs. Kashin-Beck Disease
Objective:To identify an accurate blood-based gene signature for early detection of Kashin-Beck disease (KBD). Methods: Gene expression analysis was conducted of peripheral blood samples from 100 patients with KBD and 100 controls randomly chosen from two KBD-endemic areas Two-condition experiment, ...
ORGANISM(S): Homo sapiens 
2014-07-16 | E-GEOD-59446 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Kashin-beck disease and osteoarthritis
We compared genome-wide gene expression profiles of articular cartilage derived from 4 Kashin-beck disease patients and 4 Primary osteoarthritis. Total RNA was isolated from cartilage samples following by being amplified, labeled and hybridized to Agilent Human 4M-W44k Whole Genome microarray (G4112...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MEXP-3474 | biostudies-arrayexpress
TranscriptomicsGenome-wide Gene Expression profiles of Kashin-Beck Disease
We compared genome-wide gene expression profiles of articular cartilage derived from 4 KBD patients and 4 normal controls. Total RNA was isolated from cartilage samples following by being amplified, labeled and hybridized to Agilent human 1A 22k microarray chip(G4110B).
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-3196 | biostudies-arrayexpress
ProteomicsIloprost (2/5 nM) stimulated Platelets
TiO2 enriched phosphopeptides of Iloprost stimulated platelets were digested with trypsin and labeled with iTRAQ. Samples were analysed by nano LC-MS/MS on an LTQ OrbitrapVelos (Thermo Scientific) coupled to an Ultimate 3000 Liquid Chromatography system (Dionex). Peptides were concentrated on a self...
ORGANISM(S): Homo sapiens (Human) 
2013-12-02 | PXD000242 | Pride
Phosphopeptides Itraq Iloprost Platelets 
TranscriptomicsPeripheral blood mononuclear cells, control vs. Kashin-Beck Disease
Objective: To investigate the differences between the gene expression profiles in peripheral blood mononuclear cells (PBMC) from normal controls and patients with Kashin-Beck disease (KBD). Methods: Twenty KBD patients and 12 normal subjects were selected from a KBD-endemic area and divided into fou...
ORGANISM(S): Homo sapiens 
2011-09-23 | GSE32127 | GEO
ProteomicsGlycopeptide analysis of A549 cells after influenza A infection
Influenza A virus (IAV) hijacks host cellular machinery, but many virus–IAV interactions and contacting protein sites remain uncharacterised, particularly those dependent on intact cellular architecture, such as membrane-associated or phase-separated compartments. Here, we applied in-cell cross-link...
ORGANISM(S): Influenza A virus (A/India/P063078/2006(H3N2)) Homo sapiens (Human) 
2026-04-23 | PXD072851 | Pride
Human Glycopeptide Lc-ms Influenza a 
UnknownNormative Data for the Swedish Versions of the Beck Anxiety Index and Beck Depression Inventory-Version 2.
Not available
S-EPMC12371443 | biostudies-literature
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