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GenomicsPolII Rpb3 ChIP-seq data from D. melanogaster
We performed Pol II ChIP-seq experiments with 3rd instar larva salivary glands material from male, female and MSL2 RNAi D.melanogaster, as well as from S2 cell lines material. The antibody used recognizes the Rpb3 subunit of RNA Pol II irrespective of the phosphorylation state of the Rpb1 carboxy-te...
ORGANISM(S): Drosophila melanogaster 
2012-07-27 | E-MTAB-1112 | biostudies-arrayexpress
ProteomicsProteome analysis of skeletal muscle of DMD, BMD and WT pigs
Duchenne muscular dystrophy is a fatal X-linked disease caused by mutations in the DMD gene, leading to the absence of dystrophin and progressive degeneration of skeletal and cardiac muscles. Pigs lacking DMD exon 52 (DMDΔ52) are a clinically severe model for DMD, mimicking molecular, functional, an...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-03-12 | PXD064879 | Pride
Duchenne muscular dystrophy Pig model Becker muscular dystrophy Muscle 
ProteomicsSystemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52
Duchenne muscular dystrophy (DMD) is a fatal X-linked disease caused by mutations in the dystrophin (DMD) gene, leading to the complete absence of DMD and progressive degeneration of skeletal and heart muscles. Expression of an internally shortened dystrophin in DMD subjects (DMDΔ52) can be achieved...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-11 | PXD039533 | Pride
Becker muscular dystrophy Proteomics Duchenne muscular dystrophy Pig model 
ProteomicsEngineering Transcriptional Regulation of Pentose Metabolism in Rhodosporidium toruloides for Improved Conversion of Xylose to Bioproducts
Discovery proteomics on three R. toruloides strains with differing Pnt1 expression (WT IFO 0880, OE-Pnt1, and delta Pnt1) grown on either xylose or xylose and glycerol at mid-log phase.
ORGANISM(S): Rhodosporidium Toruloides Np11 (ncbitaxon:1130832) 
2022-07-21 | MSV000089938 | MassIVE
UnknownHuman prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade.
Not available
S-EPMC3735346 | biostudies-literature
UnknownClinically significant responses achieved with romidepsin across disease compartments in patients with cutaneous T-cell lymphoma.
Not available
S-EPMC4732431 | biostudies-literature
ProteomicsMolecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
Otu2-driven deubiquitylation of ribosomal protein eS7 impacts translational efficiency. Here, authors provide the molecular basis for recognition of monoubiquitinated eS7 on 40S and give mechanistic insights into Otu2’s role in translation reset. In this context quantitative mass spectrometry analys...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-13 | PXD041573 | Pride
Pulldown Translation Ubiquitination Otu2 Ubp3 
UnknownMast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.
Not available
S-EPMC3999167 | biostudies-literature
TranscriptomicsTGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors (CDPs) and Directs Subset Specification Towards Conventional Dendritic Cells
Dendritic cells (DCs) in lymphoid tissue comprise conventional DCs (cDCs) and plasmacytoid DCs (pDCs) that develop from common DC progenitors (CDPs). CDPs are Flt3+c-kitintM-CSFR+ and reside in bone marrow. Here we describe a two-step culture system that recapitulates DC development from c-kithiFlt3...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-22432 | biostudies-arrayexpress
TranscriptomicsTranscriptional Biomarkers to Predict Female Mouse Liver Tumors in Rodent Cancer Bioassays - A 26 Chemical Set
Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures ...
ORGANISM(S): Mus musculus 
2010-03-08 | E-GEOD-18858 | biostudies-arrayexpress
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