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TranscriptomicsIdentification of cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and is associated with worse prognosis in heart failure patients. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the rel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-13016 | biostudies-arrayexpress
TranscriptomicsThe metalloregulatory site in Streptococcus pneumoniae AdcR, a zinc-activated MarR-family repressor
Streptococcus pneumoniae D39 AdcR (adhesion competence repressor) is the first metal-sensing member of the MarR (multiple antibiotic resistance repressor) family to be characterized. Expression profiling of a ∆adcR strain grown in liquid culture under microaerobic conditions revealed that transcr...
ORGANISM(S): Streptococcus pneumoniae 
2010-10-01 | E-GEOD-21506 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat 3 months old male Wistar animals by aorto-caval fistula reveals alterations in systemic substrate metabolism in rat volume-overload model of chronic heart failure
Abnormalities in metabolism of energetic substrates may play a role in progression of chronic heart failure (HF). The goal of the study was to examine the extent and mechanisms of metabolic alterations in rat model of chronic HF due to volume overload. Volume overload was induced in 3 months old mal...
ORGANISM(S): Rattus norvegicus 
2011-10-05 | E-MTAB-190 | biostudies-arrayexpress
TranscriptomicsAffymetrix profile of human liver progenitor cells
Human liver progenitor cells (LPCs) show therapeutic potential, however, their in vitro culture results in inadequate function and phenotypic instability reflecting incomplete understanding of in vivo processes. Foetal LPCs capable of differentiation to a hepatocyte phenotype were isolated and mRNA ...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57812 | biostudies-arrayexpress
TranscriptomicsInsights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris
Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an ingrained aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and...
ORGANISM(S): Komagataella pastoris 
2017-05-26 | E-MTAB-5124 | biostudies-arrayexpress
TranscriptomicsProfile of human liver progenitor cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-57878 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to MycobacteriumM-BM- bovis infection in vitro
Background: MycobacteriumM-BM- bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response. In the current study, we have analysed and compared the tr...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-45439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF for 6 hours
PlGF expression profile in primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF during 6 hours.
ORGANISM(S): Mus musculus 
2003-05-28 | E-MEXP-6 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation genome wide location analysis of yeast transcriptional regulators under multiple growth conditions
Genomic binding of 203 transcriptional regulatory proteins under various conditions. Hybridizations of fluorescently-labelled immunoprecipitated vs. whole-cell extract samples on S. cerevisiae intergenic arrays.
ORGANISM(S): Saccharomyces cerevisiae 
2004-09-02 | E-WMIT-10 | biostudies-arrayexpress
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