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MetabolomicsMannitol mediates the mummification behavior of Thitarodes xiaojinensis larvae infected with Ophiocordyceps sinensis
Parasites can facilitate their own spread and reproduction by manipulating insect hosts behavior, as seen in the interaction between Thitarodes xiaojinensis and Ophiocordyceps sinensis. Infection by O. sinensis leads to the mummification of T. xiaojinensis larvae, but the underlying mechanisms remai...
2024-08-23 | MTBLS10848 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine

Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and ...

2026-08-20 | MTBLS10145 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine
Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and mic...
2026-08-20 | MTBLS10141 | MetaboLights
MetabolomicsNeuropeptide SP protects against colitis and linked anxiety-like behavior via gut microbiota and metabolite inositol: A multi-omics analysis of the gut-brain axis

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interaction...

2025-11-18 | MTBLS11203 | MetaboLights
MetabolomicsTraditional Chinese medicine Dachaihu decoction alleviates abnormal behavior through regulating gut microbiota and metabolites in children with ASD

Traditional Chinese Medicine Dachaihu decoction (DCHD) has been reported to hold great promise to alleviate autism spectrum disorders (ASD), a generalized neurodevelopmental disease associated with gut microbiome dysbiosis. Health-promoting effects of DCHD on ASD children could be attributed to g...

2025-12-12 | MTBLS13501 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12482 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12483 | MetaboLights
TranscriptomicsGenotype mixing affects gene expression associated with hygienic behavior
Analysis used total RNA samples of individual brains of low hygienic strain worker bees that were derived from experimental colonies combined of low hygienic genotypes (L pure colonies) resp. low and high hygienic genotypes (L/H mixed colonies). Four-condition experiment: individuals that did perfor...
ORGANISM(S): Apis mellifera 
2012-09-24 | E-MTAB-801 | biostudies-arrayexpress
ProteomicsDifferential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model
Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomoto...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD008433 | Pride
Tmt labeling Flocculus Oculomotor behavior mouse model 
TranscriptomicsGenetic dissection of hygienic behavior
We performed gene expression studies in worker bees displaying quantitative genetic differences in hygienic behavior derived from backcrosses. We established hybrid queens and backcrossed to high and low performing hygienic behavioral sources and scored the hygienic behavior of single worker bees un...
ORGANISM(S): Apis mellifera 
2016-03-31 | E-MTAB-4142 | biostudies-arrayexpress
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