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ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsKinase inhibition rewires the HLA-I immunopeptidome in Chronic Myeloid Leukemia
Antileukemia immunity is essential for disease control and maintaining treatment-free remission in chronic myeloid leukemia (CML). Immunotherapeutic approaches hold significant promise for enhancing immune-mediated disease control. However, successful immunotherapy relies on identifying CML-associat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD076608 | Pride
Kinase inhibitors Immunopeptidomics Proteomics Cml 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-09 | MSV000087786 | MassIVE
ProteomicsTOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification
T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics represents the only unbiased method for directly identifying and characterizing naturally presented tumor-associated pepti...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD038782 | Pride
Hla Benign immunopeptidome Tumor antigen Mass spectrometry Timstof Immunopeptidome 
UnknownPCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development.
Not available
S-EPMC12001369 | biostudies-literature
ProteomicsLC-MSMS of the MHC-I immunopeptidome of human melanoma
While immune checkpoint blockade (ICB) therapy has significantly improved the outcome of metastatic melanoma and non-small cell lung cancer (NSCLC), most patients do not derive long-term benefits. Previous studies suggest that treatment failure is partly due to insufficient immune recognition of tum...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD043059 | Pride
Lc-msms Melanoma Immunopeptidome Mhc class i 
ProteomicsLC-MSMS of the MHC-I immunopeptidome of human NSCLC samples
While immune checkpoint blockade (ICB) therapy has significantly improved the outcome of metastatic melanoma and non-small cell lung cancer (NSCLC), most patients do not derive long-term benefits. Previous studies suggest that treatment failure is partly due to insufficient immune recognition of tum...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD043057 | Pride
Non-small cell lung cancer Lc-msms Immunopeptidome Mhc class i 
UnknownHLA Ligand Atlas DIA: extending the benign immunopeptidomics resource with increased sensitivity through data-independent acquisition mass spectrometry.
Not available
S-EPMC12406853 | biostudies-literature
UnknownHLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy.
Not available
S-EPMC8054196 | biostudies-literature
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