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ProteomicsProtein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells
Our work highlights a new role of SHP2 in regulating breast cancer progression by enhancing the production and secretion of the pro-metastatic cytokine IL-8. We also provide mechanistic insights into the effects of SHP2 inhibition and its downstream repercussions. Overall, this work enforces the rat...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD017219 | Pride
Phosphatase Mapk Breast cancer Cytokines Il-8 Ets1 Shp2 
TranscriptomicsA Splice Variant of HER2 Activates Key Signaling Cascades and Evokes Mammary Tumors and Metastases
The Epidermal Growth Factor Receptor 2 (ERBB2 or HER2) is amplified and overexpressed in approximately 20% of invasive breast cancers and is associated with metastasis and poor prognosis. Here we describe the role of a constitutively active splice variant of HER2 (Delta-HER2) in human mammary epithe...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-42781 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of preneoplastic Lgr5-creERT2/PIK3CAH1047R mammary subsets
This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from Lgr5-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from Lgr5-creERT2/PIK3CA H1047R and Lgr5-creERT2 control animals 4 weeks after activation of PIK3CA H1047...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-59870 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of preneoplastic K8-creERT2/PIK3CAH1047R mammary subsets
This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from K8-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from K8-creERT2/PIK3CAH1047R and K8-creERT2 control animals 4 weeks after activation of PIK3CA H1047R trans...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-65411 | biostudies-arrayexpress
TranscriptomicsPrimary TNBC tumor in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2012-01-16 | E-GEOD-35118 | biostudies-arrayexpress
TranscriptomicsBT474 tumors in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34523 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Lgr5-creERT2/PIK3CA H1047R and K8-creERT2/PIK3CA H1047R-evoked mammary tumors
This study examined the gene expression profile of mammary tumors derived from Lgr5- and K8-positive cell-of-origins Mammary tumors and reference mammary glands from control mice were collected, cryo-homogenized, total RNA was isolated and analyzed by microarray (total 25 samples).
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-59872 | biostudies-arrayexpress
TranscriptomicsMCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34524 | biostudies-arrayexpress
TranscriptomicsMCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures
The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall survival. We provide gene expression profile of the mammary epithelial cells MCF10A expressing HER2, ...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-37009 | biostudies-arrayexpress
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