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ProteomicsTrypanosoma brucei Mic40 depletome
Molecules that contribute to membrane curvature are essential for the formation of cristae, the bioenergetic subcompartments of mitochondria. Mic60 may be the oldest of these factors as its prokaryotic ortholog is also needed for bioenergetic-subcompartment formation in extant alphaproteobacteria, t...
ORGANISM(S): Trypanosoma brucei 
2025-12-01 | PXD059459 | Pride
Micos Trypanosoma Mitofilin 
ProteomicsTbPH1/TbKifX2 depletion proteome
Kinesins are motor proteins found in all eukaryotic lineages that move along microtubules to mediate Kinesins are motor proteins found in all eukaryotic lineages that move along microtubules to mediate cellular processes such as mitosis and intracellular transport. In trypanosomatids, the kinesin su...
ORGANISM(S): Trypanosoma brucei 
2022-06-30 | PXD033717 | Pride
Kinesin Trypanosoma brucei Rnai 
ProteomicsInteractome of Sec13 paralogs in Paradiplonema papillatum
The acquisition of new functions is frequently the result of gene duplication and is a major driver of evolutionary complexity. The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the n...
ORGANISM(S): Diplonema papillatum 
2023-06-14 | PXD037122 | Pride
Paralog expansion Diplonema  coatomer  membrane-trafficking  sec13  nuclear pore complex (npc)  sea/gator complex Evolutionary mechanisms 
ProteomicsTrypanosoma brucei PH1-BioID proxisome
Kinesins are motor proteins found in all eukaryotic lineages that move along microtubule tracks to mediate several cellular processes such as mitosis and intracellular transport of cargo. In trypanosomatids, the kinesin protein superfamily has undergone a prominent expansion, giving these protists o...
ORGANISM(S): Trypanosoma brucei 
2022-06-30 | PXD025802 | Pride
Trypanosoma Kinesin-like protein Bioid 
ProteomicsParadiplonema papillatum E3 interactome
In eukaryotes, pyruvate, a key metabolite produced by glycolysis, is converted by a mitochondrial pyruvate dehydrogenase complex (PDH) to acetyl-coenzyme A, which is fed into the tricarboxylic acid cycle. Two additional enzyme complexes catalyze similar oxidative decarboxylation reactions albeit usi...
ORGANISM(S): Diplonema papillatum 
2023-07-17 | PXD035043 | Pride
Paradiplonema papillatum Immunoprecipitation Pdh complex 
ProteomicsParadiplonema papillatum CENPA-V5 IP
Transmission of genetic material from one generation to the next is a fundamental feature of all living cells. In eukaryotes, a macromolecular complex called the kinetochore plays crucial roles in this process by providing linkage between chromosomes and spindle microtubules. Little is known about t...
ORGANISM(S): Diplonema papillatum 
2024-10-21 | PXD054535 | Pride
Paradiplonema Histone variant Kinetochore 
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