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ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small- Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036574 | Pride
Ubiquitin Usp30 Abpp Benzosulfonamides Hdx-ms 
UnknownStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.
Not available
S-EPMC10400906 | biostudies-literature
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041582 | Pride
Abpp-ms Usp30 Hdx-ms 
UnknownNickelII-catalyzed asymmetric photoenolization/Mannich reaction of (2-alkylphenyl) ketones.
Not available
S-EPMC9337722 | biostudies-literature
UnknownPeptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C-H activation.
Not available
S-EPMC6107497 | biostudies-literature
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo Sapiens 
2026-01-12 | PXD042782 | panorama
ProteomicsAn unconventional integrin promotes human immunityAn unconventional integrin promotes human immunity
Cancer remains one of the leading causes of mortality worldwide, with increasing public health interest towards immunological-based approach in disease treatments. Enrichment of certain cell population, namely the CD103+ tissue-resident memory T (Trm) cells has been associated with better clinical p...
ORGANISM(S): Homo sapiens (Human) 
2024-07-30 | PXD045989 | Pride
Human Cancer immunology Interactomics 
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