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MetabolomicsUHPLC-Q-TOF MS-Based Serum Metabolomics Reveals the Therapeutic Effects of Berberine and Wumei Wan on APCmin/+ Mice

APCmin/+ mice (8-week-old) and wild-type C57BL/6 controls were divided into MOD (saline), BBR (100 mg/kg berberine), WMW (17 g/kg Wu Mei Wan), and CON (saline) groups. All mice received daily gavage for 10 weeks under a 60% high-fat diet. Serum samples were collected after euthanasia and subjecte...

2025-10-16 | MTBLS12598 | MetaboLights
MetabolomicsBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights
MetabolomicsBerberine improves intestinal barrier and cognitive impairment by remodeling intestinal microbiota in C57BL/6 septic mice induced by LPS
After feeding LPS induced C57BL/6 septic mice with berberine, we performed behavioral, HE staining, ELISA, western blot, metagenomic sequencing of gut microbiota and untargeted metabolomics analysis to evaluate the effects of berberine on septic mice.
2026-06-17 | MTBLS14775 | MetaboLights
TranscriptomicsGene expression in response to fluconazole vs. the combination of fluconazole and berberine
Transcriptional profiling of Candida albicans comparing fluconazole treated cells with fluconazole- and berberine-treated cells, as well untreated cells with berberine treated cells Three different clinical FLC-resistant strains (0304103, 01010 and 632) were selected to carry out the expression prof...
ORGANISM(S): Candida albicans 
2013-11-14 | E-GEOD-43662 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of primary human hepatocytes after berberine chloride treatment
Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects. Since xenobiotic drug-induced micoRNAs have recently emerged as key regulators in guiding their pharmacological effects and toxicity, we were interested in wh...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53415 | biostudies-arrayexpress
ProteomicsBerberine treated colon cancer cells LC-MSMS
This study aims to identify the underlying crucial proteins and regulatory networks associated with berberine treatment in colon cancer by using both proteomics analyses. Overall,this study shed a light for elucidating the related regulatory signalling pathways and discovering potential targets for ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD019749 | Pride
Lc-msms Berberine Colon cancer cells 
TranscriptomicsMicroRNA expression profiling of primary human hepatocytes after berberine chloride treatment
Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects. Since xenobiotic drug-induced micoRNAs have recently emerged as key regulators in guiding their pharmacological effects and toxicity, we were interested in wh...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53413 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of HepG2 liver cells after berberine chloride treatment
Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects including anti-cancer effects. Since xenobiotic drug-induced micoRNAs have recently emerged as key regulators in guiding their pharmacological effects and toxi...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-47821 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of berberine chloride-responsive gene expression in HepG2 liver cell line
Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects. Here, we used gene expression microarray to analyze gene expression profiles of HepG2 human hepatoma cell line after berberine chloride treatment or 0.08% DM...
ORGANISM(S): Homo sapiens 
2013-10-02 | E-GEOD-47786 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of HepG2 liver cells after berberine chloride treatment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-47822 | biostudies-arrayexpress
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