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ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
TranscriptomicsThe age and genomic integrity of neurons after cortical stroke in humans
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA-rearrangements in the human neocortex. We show here that neither is the case, using immunohistochemistry, transcriptome-, genome- and ploidy-analyses, and determination of nuclear bomb test-derived 14C-concentration in ...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56267 | biostudies-arrayexpress
TranscriptomicsA dynamic role of Tbx3 in the pluripotency circuitry
Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency. Henc...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-73862 | biostudies-arrayexpress
UnknownSBML Level 3: an extensible format for the exchange and reuse of biological models.
Not available
S-EPMC8411907 | biostudies-literature
UnknownCharacteristics and outcomes of older patients undergoing out- versus inpatient surgery in Europe. A secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Not available
S-EPMC11932067 | biostudies-literature
UnknownAssociation between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Not available
S-EPMC8815825 | biostudies-literature
UnknownPeri-interventional outcome study in the elderly in Europe: A 30-day prospective cohort study.
Not available
S-EPMC8815832 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
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