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UnknownUbiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.
Not available
S-EPMC5823975 | biostudies-literature
ProteomicsTargetSeeker-MS: A Bayesian Inference Approach for Drug Target Discovery using Protein Fractionation Coupled to Mass Spectrometry
Determining the affinity of a drug to its putative targets is critical to the understanding of its mechanism and to assess its clinical usefulness and viability. Energetics-based protein separation (EBPS) techniques, such as thermal shift assay, when coupled to mass spectrometry (MS) have shown grea...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-04-06 | PXD010799 | Pride
Bioinformatics / drug target discovery / mass spectrometry / proteomics / thermal shift assay 
TranscriptomicsRNA-Seq in liver of Tc1 mice carrying human chromosome 21 passaged through either the female or male germline
This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom...
ORGANISM(S): Mus musculus 
2016-11-16 | E-MTAB-4912 | biostudies-arrayexpress
ProteomicsPaleofeces Analysis from Iron Age Hallstatt Salt Miners
Paleofeces are an important source of information to study the evolution of dietary habits and human health. The UNESCO World Heritage region of Hallstatt-Dachstein/Salzkammergut is one of Europe’s oldest cultural and industrial landscapes; its underground salt mines dating back at least to the 14th...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027613 | Pride
Human Iron age Hallstatt Ancient Feces Salt mine Paleofeces 
ProteomicsUbiquitin-mediated modulation of necroptotic effector MLKL
We aimed to identify lysine (K) residues that are endogenously ubiquitylated upon TNF-induced necroptosis. To this end, we used a quantitative mass spectrometry-based approach. Briefly, MDFs were treated with TSZ or left untreated and protein lysates were digested with trypsin into peptides. Ubiquit...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD018857 | Pride
Ubiquitin Tmt Cancer Mlkl Mouse Msms 
TranscriptomicsRNA-seq of liver tissue and liver cancer cell lines
This dataset has been designed to test whether codons in mRNAs and anticodons in tRNAs vary in order to maximize translation in specific cellular conditions in mammals. Prokaryotes and simple unicellular eukaryotes optimize their translational rates by adjusting the codons in the protein-coding tran...
ORGANISM(S): human 
2016-04-18 | E-MTAB-4052 | biostudies-arrayexpress
UnknownMachine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA.
Not available
S-EPMC6708173 | biostudies-literature
UnknownUbiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Not available
S-EPMC8184782 | biostudies-literature
UnknownRIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Not available
S-EPMC6375735 | biostudies-literature
UnknownThe International Climate Psychology Collaboration: Climate change-related data collected from 63 countries.
Not available
S-EPMC11445540 | biostudies-literature
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