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MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
UnknownBiomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank.
Not available
S-EPMC4648162 | biostudies-literature
UnknownHeritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of miR-137.
Not available
S-EPMC10521919 | biostudies-literature
UnknownFunctional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.
Not available
S-EPMC2640212 | biostudies-literature
UnknownA complex network approach reveals a pivotal substructure of genes linked to schizophrenia.
Not available
S-EPMC5755767 | biostudies-literature
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
UnknownThe site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.
Not available
S-EPMC514586 | biostudies-literature
UnknownMachine learning-based ability to classify psychosis and early stages of disease through parenting and attachment-related variables is associated with social cognition.
Not available
S-EPMC7989088 | biostudies-literature
UnknownA numerical study towards shape memory alloys application in orthotic management of pediatric knee lateral deviations.
Not available
S-EPMC9902535 | biostudies-literature
ProteomicsThe self-peptide repertoire plays a critical role in transplant tolerance induction
While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly-alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically-engineered MHC I constructs, mice with a hepatocyt...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD023015 | Pride
Immunopeptidomics Hla Transplantation 
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