Sort   by:  
 Page size 
ModelsCoggins2014 - CXCL12 dependent recruitment of beta arrestin
Nathaniel L. Coggins, Danielle Trakimas, S. Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E. Luker, Jennifer J. Linderman & Gary D. Luker. CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. PLoS ONE 9, 6 (2014). Chemokine CXCL12 promotes growth a...
2024-09-02 | BIOMD0000000599 | BioModels
ProteomicsMolecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
Arrestins are a protein family that regulate G protein-coupled receptor (GPCR) signaling, with four distinct members in mammals (arrestin 1–4). Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in C-terminus release. This induces further allosteric co...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-15 | PXD049391 | Pride
Arrestin Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 5-bisphosphate Phosphatidylinositol 4 
ProteomicsMolecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2
G protein-coupled receptors (GPCRs) are essential signaling molecules involved in various physiological processes, with β-arrestins playing crucial roles in receptor desensitization, internalization, and G protein-independent signaling. Although the interaction between the phosphorylated C-terminal ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD056442 | Pride
Arrestin Dopamine receptor d2 Phosphorylated intracellular loop 3 Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 
GenomicsLung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
Lung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
PRJNA432928 | ENA
ProteomicsIntrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
G protein-coupled receptors (GPCRs) are typically characterized by their seven transmembrane (7TM) architecture, and interaction with two universal signal-transducers namely, the heterotrimeric G-proteins and β-arrestins (βarrs). Synthetic ligands and receptor mutants have been designed to elicit tr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027887 | Pride
Gpcr kinases Gpcrs Β-arrestins Complement c5a Biased signaling Β-arrestin-coupled receptors Seven transmembrane receptors 
TranscriptomicsLung transcriptomes of wild type, β-arrestin 1 -/-, and β-arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
We found that β-arrestin 1 -/- mice were more sensitive to hypoxia-induced pulmonary arterial hypertension with increased right ventricle hypertrophy and higher right ventricle systolic pressure, while β-arrestin 2 -/- mice developed right ventricle hypertrophy comparable to wild type mice. Moreover...
ORGANISM(S): Mus musculus 
2018-11-19 | GSE110131 | GEO
TranscriptomicsImpact of beta-arrestin-2 deficiency on intestinal tumorigenesis in Apc-mutated mice
This SuperSeries is composed of the following subset Series: GSE24575: Beta-arrestin-2 deficiency effect on intestinal tumorigenesis in Apc-mutated mice GSE24576: Gene expression analysis of tumors from ApcD14/+ mice Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-24577 | biostudies-arrayexpress
Genomicsβ-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion
β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion
PRJNA670348 | ENA
TranscriptomicsImpact of G protein versus beta-arrestin-dependent signal transduction at the FSH receptor (affy_fsh_human)
affy_fsh_human - affy_fsh_human - - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G p...
ORGANISM(S): Homo sapiens 
2011-11-25 | E-GEOD-21982 | biostudies-arrayexpress
ProteomicsThe interactions between β-Arrestin 1 and Gαs or Gαi1: functional and structural insights
G proteins and arrestins are key G protein-coupled receptor (GPCR) signaling transducers, mediating distinct downstream pathways. Recent evidence suggests that G proteins and β-arrestins (βarrs) can directly or functionally interact through GPCR–G protein–βarr megaplexes, direct βarr1–Gαs interactio...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD065019 | Pride
G protein Protein–protein interaction Aarrestin Gpcr signaling 
Sort   by:  
 Page size