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ProteomicsGATAD2B O-GlcNAcylation regulates breast cancer stem-like potential and drug resistance
The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). In breast cancer, the function and maintenance of CSCs are influenced by protein O-GlcNAcylation and the enzyme responsible for this po...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058744 | Pride
Cancer stem cell Cancer Nurd Gatad2b : ogt O-glcnac Signaling Chemoresistance 
ProteomicsDefining the Tumor Microenvironment by Integration of Im-munohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry
Breast stroma plays a significant role in breast cancer risk and progression yet remains poorly understood. In breast stroma, collagen is the most abundantly expressed protein and its increased deposition and alignment contributes to progression and poor prognosis. Collagen post-translation modifica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028107 | Pride
Imaging mass spectrometry (ims)  immunohistochemistry (ihc)  pten  stroma  ecm  tumor microenvironment  breast cancer 
ProteomicsProteomic Discoveries in hypermobile Ehlers Danlos Syndrome (hEDS) Reveals Insights into Disease Pathophysiology
Objectives: Hypermobile Ehlers-Danlos Syndrome (hEDS) is a prevalent but poorly understood connective tissue disorder lacking molecular diagnostic markers. This study aimed to identify proteomic biomarkers in hEDS to elucidate underlying pathophysiology and support objective diagnostic and therapeut...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD062941 | Pride
Ehlers danlos syndrome (heds) Dia Serum Elisa 
ProteomicsSpatial omics based machine learning (SOML) algorithms for the early detection of hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is the seventh most common cancer in the world and accounts for over 800,000 deaths annually, making it the second most lethal cancer. Poor chemotherapeutic agents against HCC have necessitated the importance of early detection and surgical intervention in patient mana...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047546 | Pride
Glycan Spatial-omics Hcc Imaging Maldi_tof 
ProteomicsTLR9-activated B cells imprint adoptively transferred CD8+ T cells with potent tumor immunity and persistence
Here we report a new way to reverse the tolerant state of adoptively transferred CD8+ T cells against melanoma through ex vivo expansion with the TLR9 agonist CpG. CpG-generated T cells elicited potent immunity without co-administration of high dose IL-2 or vaccination, which are adjuvants classical...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD022909 | Pride
T cells adoptive cell transfer therapy toll-like receptors melanoma b cells 
ProteomicsAdaptative changes in protein expression and lysine acetylation induced by decreased glutathione levels in astrocytes
Astrocytes and neurons form a highly specialized functional unit and the loss or gain of astrocytic functions can influence the initiation and progression of different neurodegenerative diseases. Neurons depend on the antioxidant protection provided by neighboring astrocytes. Glutathione (-l-glutamy...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-24 | PXD001834 | Pride
Acetyl Astrocytes Silac 
ProteomicsIntegrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans
Circulating osteoprogenitor (COP) are a population of cell in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). While there is functional overlap, it is not known how COP cells are related to bone marrow (BM)-derived MSCs (BM-MSC...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD035803 | Pride
Circulating osteoprogenitor cell  circulating osteogenic precursor  multilineage stromal cells  adipose-derived stromal cells. 
ProteomicsSSc biomarkers detection in the secretome of TGF1-activated primary human lung fibroblasts.
TGFβ1 is a profibrotic mediator that contributes to a broad spectrum of pathologies, including pulmonary fibrosis (PF). However, the secretome of TGFβ1-stimulated primary human normal lung (NL) fibroblasts has not been well characterized. Using fluorescent 2-dimensional gel electrophoresis (2D-PAGE)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023862 | Pride
Tgfbeta Fibroblasts Secretome 
ProteomicsProximity-dependent biotinylation detects association between stress granule associated proteins and SARS coronavirus nonstructural protein 1
Severe acute respiratory syndrome coronavirus (SARS-CoV and SARS-CoV-2) nonstructural protein 1 (nsp1) is a critical viral protein that suppresses host gene expression by blocking the assembly of the ribosome on host messenger RNAs (mRNA). Using proximity-dependent biotinylation assay followed by pr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025980 | Pride
Nsp1 Stress granule Sars-cov Sars-cov-2 Bioid2 
ProteomicsAntiviral HCV Treatment Induces Rapid Proteomic and Phospho-proteomic Changes in Hepatic Interferon and ERK1/2 Signaling Pathways
Although treatment of chronic hepatitis C virus (HCV) infection with direct acting antivirals (DAAs) results in high rates of cure, liver fibrosis does not resolve immediately after HCV eradication. Resolution of fibrosis occurs in some, but not all patients, after HCV cure, and hepatic decompensati...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024846 | Pride
Phosphoproteomics Hcv Liver biopsy Proteomics Daa 
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